Coexistence of osteopoikilosis with seronegative spondyloarthritis and spinal stenosis

[Purpose] Osteopoikilosis is a rare hereditary bone disease that is usually asymptomatic.It is generally diagnosed incidentally on plain radiography. The coexistence ofosteopoikilosis with seronegative spondyloarthritis or spinal stenosis is rarely reported.Here, we report the case of a 27-year-old male patient with osteopoikilosis, seronegativespondyloarthritis, and spinal stenosis. [Subject] A 27-year-old male patient with buttockpain and back pain radiating to the legs. [Methods] A plain anteroposterior radiograph ofthe pelvis revealed numerous round and oval sclerotic bone areas of varying size.Investigation of the knee joints showed similar findings, and the patient was diagnosedwith osteopoikilosis. Lumbar magnetic resonance images showed spinal stenosis anddegenerative changes in his lumbar facet joints. Magnetic resonance images of thesacroiliac joints showed bilateral involvement with narrowing of both sacroiliac joints,nodular multiple sclerotic foci, and contrast enhancement in both joint spaces andperiarticular areas. HLA B-27 test was negative. [Results] The patient was diagnosed withosteopoikilosis, seronegative spondyloarthritis, and spinal stenosis. Treatment includedasemetasin twice daily and exercise therapy. [Conclusion] Symptomatic patients withosteopoikilosis should be investigated for other possible coexisting medical conditions;this will shorten the times to diagnosis and treatment.Key words: Osteopoikilosis, Spinal stenosis, Spondyloarthritis