加味清营汤对寻常型银屑病血热证患者炎症因子及免疫功能的影响

目的:探讨加味清营汤在寻常型银屑病血热证患者治疗中的应用价值,观察其对炎症因子、免疫功能的影响。方法:采用随机数字表法将98例寻常型银屑病血热证患者分为对照组和观察组。对照组49例采用西医常规治疗,观察组49例在对照组基础上联合加味清营汤治疗。治疗后比较两组巨噬细胞集落刺激因子(M-CSF)、血管内皮生长因子(VEGF)、白介素-6(IL-6)、白介素-17(IL-17)、CD4⁺、CD3⁺、CD4⁺/CD8⁺、银屑病皮损面积及严重程度指数(PASI)评分,比较两组疗效及不良反应发生情况。结果:治疗后观察组血清M-CSF、VEGF水平低于对照组,差异有统计学意义(均P<0.05)。治疗后观察组血清IL-6、IL-17水平低于对照组,差异有统计学意义(均P<0.05)。治疗后观察组血清CD4⁺、CD3⁺、CD4⁺/CD8⁺、水平低于对照组(均P<0.05)。治疗后观察组第2周、第4周时PASI评分低于对照组,差异有统计学意义(均P<0.05)。治疗后观察组总有效率93.88%,高于对照组的73.47%,差异有统计学意义(P<0.05)。观察组不良反应发生率14.29%高于对照组的12.24%,差异无统计学意义(P>0.05)。结论:加味清营汤联合西药治疗寻常型银屑病血热证患者可抑制炎症反应,调节免疫功能,抑制血管新生,改善患者症状,疗效较好。

Effect of modified Qingying decoction on inflammatory factor and immune function in patients with psoriasis vulgaris of Xuere syndrome

Objective:To explore application value of modified Qingying decoction in the treatment of patients with psoriasis vulgaris of Xuere syndrome and observe its effect on inflammatory factor and immune function.Methods:98 patients with psoriasis vulgaris of Xuere syndrome were divided into the control group and the observation group by random number table method.49 cases in the control group were treated with conventional western medicine,and 49 cases in the observation group were treated on the basis of the control group combined with modified Qingying decoction.After treatment,the serum macrophage colony-stimulating factor(M-CSF),vascular endothelial growth factor(VEGF),interleukin-6(IL-6),interleukin-17(IL-17),CD4⁺,CD3⁺,CD4⁺/CD8⁺,psoriasis skin lesion area and severity index(PASI),adverse reaction rate and effect were compared between the two groups.Results:After treatment,the serum M-CSF and VEGF levels of the observation group were significantly lower than those in the control group(all P<0.05).After treatment,the serum interleukin-6(IL-6)and interleukin-17(IL-17)levels of the observation group were significantly lower than those in the control group(all P<0.05).After treatment,the serum CD4⁺,CD3⁺,CD4⁺/CD8⁺ levels of the observation group were lower than those in the control group(all P<0.05).After treatment,the PASI score at the second week and the forth week of the observation group were significantly lower than those in the control group(all P<0.05).The total effective rate of the observation group was 93.88% significantly higher than that in the control group 73.47%(P<0.05).The total rate of adverse reactions in the observation group was 14.29% higher than that in the control group 12.24%,difference not statistically significant(P>0.05).Conclusion:Modified Qingying decoction combined with western medicine has remarkable effect on patients with psoriasis vulgaris of Xuere syndrome,which can inhibit inflammatory response,regulate immune function,inhibit angiogenesis,improve patient's symptoms,and adverse reactions.