褪黑激素对精神分裂症小鼠行为及氧化应激的影响

目的探讨褪黑激素对精神分裂症小鼠行为及氧化应激的影响。方法制备小鼠精神分裂症模型,第15天开始,利培酮组小鼠灌胃给予利培酮(0.025 mg/kg),褪黑素组小鼠灌胃给予褪黑素(5 mg/kg),对照组和模型组小鼠灌胃给予等量生理盐水,连续14 d后测定相关指标。结果与对照组比较,其他3组小鼠社会交往时间和穿越平台次数减少,跨格总数和逃避潜伏期增加,脑组织中丙二醛(MDA)和一氧化氮(NO)含量显著升高,谷胱甘肽(GSH)含量显著降低(P<0.05);与模型组比较,利培酮组和褪黑素组小鼠社会交往时间和穿越平台次数增加,跨格总数和逃避潜伏期降低,脑组织中MDA和NO含量显著降低,GSH含量显著增加(P<0.05);利培酮组和褪黑素组小鼠各指标的差异不显著(P>0.05)。结论褪黑激素能减轻精神分裂症模型小鼠的行为异常症状,可阻断大脑氧化应激反应。

Melatonin on Behavior and Oxidative Stress in Mice with Schizophrenic

Objective To explore the effect of melatonin on behavior and oxidative stress in mice with schizophrenic.Methods A mouse model of schizophrenia was established.From the 15th day,the mice in the risperidone group were administrated with risperidone(0.025 mg/kg),and the mice in the melatonin group were administrated with melatonin(5 mg/kg),the rats in control group and model group were administrated with normal saline,and the related indexes were measured after 14 days of continuous treatment.Results Compared with the control group,the social interaction time and the number of crossing platforms of the other three groups decreased,the total number of crossing grids and escape latency increased,the content of malondialdehyde(MDA)and nitric oxide(NO)in brain tissue increased significantly,and the content of glutathione decreased significantly(P<0.05).Compared with the model group,the risperidone group and melatonin group increased social interaction time and the number of crossing platforms,the total number of cross-grids and escape latency decreased,and the content of MDA and NO in the brain tissue was significantly reduced,and the peptide content increased significantly(P<0.05);the differences between the indexes in the risperidone group and the melatonin group were not significant(P>0.05).Conclusion Melatonin can alleviate behavioral abnormalities in schizophrenic model mice and block oxidative stress in the brain.