Alcohol consumption and mortality: a dose-response analysis in terms of time |
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| Affiliation: | 1. Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;2. Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;1. slowCapital Pty Ltd, Melbourne, Australia;2. Population Health, Murdoch Childrens Research Institute, Royal Children''s Hospital Melbourne, Parkville, Victoria, Australia;3. Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia;1. Institute for Applied Health Research, School of Health and Life Sciences, Glasgow Caledonian University, UK;2. School of Mechanical and Systems Engineering, Newcastle University, UK;3. Peacocks Medical Group Ltd., Newcastle upon Tyne, UK;1. National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA;2. School of Public Health, University of Illinois, Chicago;3. Waisman Center, University of Wisconsin-Madison;4. Medical University of South Carolina, Charleston;5. School of Public Health, University of South Florida, Tampa;6. College of Public Health, University of Alabama-Birmingham;1. The Ohio State University College of Nursing, Columbus;2. Department of Sociology, The Ohio State University, Columbus |
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| Abstract: | PurposeLow-to-moderate alcohol consumption is associated with decreased mortality. However, many aspects of this association are still debated. Our aim was to complement available information by conducting a dose-response analysis of the association between alcohol consumption and survival time.MethodsIn a Swedish population-based cohort of 67,706 middle-aged and elderly men and women, frequency and amount of drinking were assessed through a self-administrated questionnaire. During 15 years of follow-up, 13,323 participants died. Differences in survival (10th percentile differences, PDs) according to levels of alcohol consumption were estimated using Laplace regression.ResultsWe found evidence of nonlinearity between alcohol consumption and survival. Among women, we observed a rapid increase in survival up to 6 g/d of alcohol consumption (0.5 drinks/d) where survival was 17 months longer (PD = 17 months, 95% confidence interval, 10 to 24). After this peak, higher alcohol consumption was progressively associated with shorter survival. Among men, survival improved up to 15 g/d (1.5 drinks/d) where we observed a PD of 15 months (95% confidence interval, 8 to 22).ConclusionsLow alcohol consumption was associated with improved survival up to 1.5 years for women with an average consumption of 0.5 drinks per day and to 1.3 years for men with an average consumption of 1.5 drinks per day. |
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| Keywords: | Alcohol Mortality Survival Percentile Laplace Dose-response |
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