Breast Cryoablation in Patients with Bone Metastatic Breast Cancer |
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| Institution: | 1. Division of Interventional Radiology, Ocological Hospital “A. Businco,” Regional Referral Center for Oncologic Diseases, Cagliari 09100, Italy;2. Department of Oncological Radiology, Ocological Hospital “A. Businco,” Regional Referral Center for Oncologic Diseases, Cagliari 09100, Italy;3. Complex Operative Unit of Radiology, Institute of Radiological Sciences, University of Sassari, Sassari, Italy;1. Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo;2. Department of Radiology, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan;1. Department of Radiology, Reading Health System, 6th and Spruce Streets, West Reading, PA 19611;2. Department of Surgery, Reading Health System, 6th and Spruce Streets, West Reading, PA 19611;1. Vascular and Interventional Radiology Center, Johns Hopkins Hospital, Baltimore, MD 21287;2. Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, MD 21287;1. Department of Radiology, Second Xiangya Hospital, Central South University, No 139 Middle Renmin Road, Changsha, Hunan, 410011, People’s Republic of China;2. Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania;3. Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania;4. Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania;5. Yale School of Medicine, New Haven, Connecticut;1. Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan;2. Hitachi Medical Corporation, 2-1 Shintoyofuta, Kashiwa, Chiba 277-0804, Japan;3. KKR Sapporo Medical Center Tonan Hospital, N1 W6, Chuo-ku, Sapporo 060-0001, Japan;1. Department of Radiology and Imaging Sciences, Divisions of Interventional Radiology and Image-guided Medicine Emory University School of Medicine, 1364 Clifton Road NE, Suite D112, Atlanta, GA 30322;2. Pediatric Radiology, Emory University School of Medicine, 1364 Clifton Road NE, Suite D112, Atlanta, GA 30322;3. Department of Orthopaedics, Emory University School of Medicine, 1364 Clifton Road NE, Suite D112, Atlanta, GA 30322;4. Children’s Orthopaedics of Atlanta (J.A.F.), Atlanta, Georgia;5. Atlanta VA Medical Center, Atlanta, Georgia |
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| Abstract: | PurposeTo assess retrospectively the safety and feasibility of palliative breast cryoablation to treat primary breast tumors in patients with stage IV breast cancer.Materials and MethodsIn 17 female patients (mean age ± SD, 59 y ± 13; range, 37–81 y) with 22 bone metastatic ductal invasive breast lesions (2.5 cm × 1.6 cm ± 1.4 × 1.1; range, 1.0 cm × 0.5 cm to 6.7 cm × 5.5 cm), 19 computed tomography (CT)–guided percutaneous cryoablation sessions were performed for treatment of primary breast tumors. All patients had radiologic evidence (contrast-enhanced CT or magnetic resonance imaging) of persistence or progression of the primary breast cancer despite systemic therapy. The radiologic outcome was evaluated with a mean follow-up period of 13 months (range, 3–31 mo). Treatment of skeletal metastases was unnecessary during the follow-up period.ResultsAll of the cryoablation sessions were completed and well tolerated. Complete regression of the disease was achieved in 15 (88%) patients 2 months after the cryoablation. Two (12%) patients underwent a second cryoablation treatment because of a minimal persistence of viable tumor (residual disease). No relapse of primary tumors was observed on breast imaging during the follow-up period. One patient (6%) developed a new lesion localized to the contralateral breast.ConclusionsThese data suggest that palliative cryoablation of primary advanced breast cancer is a well-tolerated, feasible, and effective treatment option. Given the palliative effects of breast cryoablation demonstrated in this series, larger studies replicating these results are warranted. |
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