眼用制剂中抑菌剂的使用

由于直接与较为脆弱的眼部接触,眼用制剂对安全性要求极高,而为了保证无菌环境,多数眼用制剂中加入了抑菌剂用于防止其在使用和保存过程中被微生物污染。然而起到灭菌作用的同时,抑菌剂却也有损伤眼表的可能。随着人们逐渐关注到这个问题,未添加抑菌剂的眼用制剂或许会更受青睐。

The Use of Bacteriostatic Agents in Ophthalmic Preparations

Because of direct contact with the fragile eye, eye preparations require high safety. In order to ensure a sterile environment, most eye preparations are added with bacteriostatic agents to prevent microbial contamination during use and preservation. However, while sterilizing, the bacteriostat may also damage the ocular surface. As people gradually realize this problem, ophthalmic preparations without bacteriostasis may be more popular.