Large Pulmonary Arteriovenous Malformations: Long-Term Results of Embolization with AMPLATZER Vascular Plugs |
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| Institution: | 1. School of Radiology, Università degli Studi di Milano, Via Antonio di Rudinì, 8, 20142 Milano, Italy;2. Department of Radiology Interventistica, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy;1. Department of Interventional Radiology, First Affiliated Hospital of Soochow University, 188 Shizi St., 215006 Suzhou, China;2. Department of Radiology, Changhai Hospital, Shanghai, China;3. Division of Neurosurgery, Department of Surgery, Taipei Cathay General Hospital, Taipei, Taiwan;4. School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan;1. Department of Radiology, National Hospital Organization Beppu Medical Center, Oita, Japan;2. Department of Radiology, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu 874-0838, Japan;3. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University Hospital, Fukuoka, Japan;1. Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-361, San Francisco, CA 94143;2. Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, M-361, San Francisco, CA 94143 |
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| Abstract: | PurposeTo analyze the long-term results of endovascular treatment of large pulmonary arteriovenous malformations (PAVMs) using the AMPLATZER vascular plug (AVP; AGA Medical Corp, Golden Valley, Minnesota).Materials and MethodsBetween May 2007 and April 2011, 18 patients with 24 large PAVMs, defined as PAVMs that had a feeding artery with a diameter of ≥ 8 mm, were treated with AVP I or AVP II. A single AVP device was used for each PAVM. Aneurysmal sac diameters, sac perfusion, sac shrinkage, and complete resolution before and after the intervention were analyzed. Complete histories, laboratory values, physical examinations, and multidetector computed tomography images were reviewed. The mean occlusion time for AVP I and AVP II and the mean arterial oxygen saturation (SaO2) before and after the intervention were compared.ResultsThe mean diameter of the feeding artery was 11.46 mm ± 2.18 (range, 8–13.3 mm). The mean occlusion time was 7.34 minutes ± 1.23 for AVP I and 6.25 minutes ± 1.12 for AVP II (P = .11). The mean SaO2 before and after the intervention was 63.71% ± 8.10% (range, 51%–76%) and 96.28% ± 0.49% (range, 96%–97%), respectively (P = .045). No major periprocedural complications were observed. The mean follow-up duration was 36.33 months ± 10.63 (range, 28–56 mo). During the follow-up period, there were no persistent sac perfusions, migration of the AVPs, major complications, or recanalizations.ConclusionsTreatment of large PAVMs with AVPs is an effective method for obtaining excellent long-term results. Embolization of large feeding arteries can be accomplished with AVPs without major complications. |
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| Keywords: | AVP"} {"#name":"keyword" "$":{"id":"key0010"} "$$":[{"#name":"text" "_":"AMPLATZER vascular plug PAVM"} {"#name":"keyword" "$":{"id":"key0020"} "$$":[{"#name":"text" "_":"pulmonary arteriovenous malformation arterial oxygen saturation |
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