瓜蒌薤白半夏汤合失笑散加减治疗冠心病心绞痛临床研究

目的:探讨瓜蒌薤白半夏汤合失笑散加减治疗对冠心病心绞痛患者心功能、血脂水平及抗氧化指标的影响研究。方法:将冠心病心绞痛患者70例随机分为对照组和观察组各35例,对照组患者给予常规药物治疗,观察组在此基础上,加用瓜蒌薤白半夏汤合失笑散加减治疗。比较两组患者治疗后临床疗效、中医症候积分、心功能指标、血脂水平及抗氧化指标变化。结果:治疗后,观察组患者总有效率(94.29%)显著高于对照组(74.29%)(P<0.05); 两组患者中医症候积分均较治疗前显著降低(P<0.05),两组比较差异有统计学意义(P<0.05); 两组患者心功能指标LVEF、CI、CO及SV均较治疗前显著升高(P<0.05),两组比较差异有统计学意义(P<0.05); 两组患者TC、TG及LDL-C水平均较治疗前显著降低(P<0.05),HDL-C水平较治疗前显著升高(P<0.05),两组比较差异均有统计学意义(P<0.05); 两组患者指标SOD、CAT及GSH-Px均较治疗前显著升高(P<0.05),指标LPO较治疗前显著降低(P<0.05),且观察组与对照组比较差异均有统计学意义(P<0.05)。结论:瓜蒌薤白半夏汤合失笑散加减治疗冠心病心绞痛患者临床疗效显著,可有效提高患者心功能,改善血脂水平及抗氧化指标。

Clinical Study on Gualou Xiebai Banxia decoction and Shixiao powder modified in treating coronary heart disease angina pectoris

Objective:To explore the effect of modified Gualou Xiebai Banxia decoction with Shixiao powder on cardiac function,blood lipids levels and antioxidant indicators in patients with coronary heart disease complicated with angina pectoris.Methods:70 patients with coronary heart disease complicated with angina pectoriswere were randomly divided into control group and observation group,with 35 cases in each group.Control group received conventional medicine treatment,and observation group was additionally treated with modified Gualou Xiebai Banxia decoction with Shixiao powder on this basis.The clinical efficacy,TCM symptoms scores,cardiac function indexes,blood lipids levels and antioxidant indicators were compared between the two groups of patients after treatment.Results:After treatment,the total effective rate of observation group was significantly higher than that in control group(P<0.05).The scores of TCM symptoms in the two groups were significantly decreased compared with those before treatment(P<0.05),and the observation group were significantly different from those in control group(P<0.05).The cardiac function indexes of LVEF,CI,CO and SV of the two groups were significantly increased compared with those before treatment(P<0.05),and the observation group were significantly different from those of control group(P<0.05).The levels of TC,TG and LDL-C in the two groups were significantly decreased compared with those before treatment(P<0.05).While the level of HDL-C was significantly increased compared with that before treatment(P<0.05),and observation group were significantly different from those in control group(P<0.05).The levels of SOD,CAT and GSH- Px in the two groups were significantly increased compared with those before treatment(P<0.05).While the level of LPO was significantly decreased compared with that before treatment(P<0.05),and there were significant differences between observation group and control group(P<0.05).Conclusion: Modified Gualou Xiebai Banxia decoction with Shixiao powder has a significant clinical effect in the treatment of patients with coronary heart disease complicated with angina pectoris,and it can effectively enhance the cardiac function,and improve blood lipids levels and antioxidant indicators.