Psychiatric diseases predated the occurrence of Parkinson disease: a retrospective cohort study |
| |
| Institution: | 1. Parkinson''s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA;2. Mental Illness Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA;3. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;4. Department of Veterans Affairs, HSR&D Center for Clinical Management Research, Ann Arbor, MI, USA;5. Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, MI, USA;6. Morton and Gloria Shulman Movement Disorder Centre and the Edmond J Safra Program in Parkinson''s Disease, Toronto Western Hospital, University of Toronto, Canada;7. Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA;8. Geriatric Research, Education and Clinical Center, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA |
| |
| Abstract: | PurposeThe influence of mental illness early in life on the subsequent risk of Parkinson disease (PD) and its clinical picture remain obscure. This study investigated the effects of psychiatric diseases on a subsequent PD diagnosis.MethodsWe used the Longitudinal Health Insurance Database 2000 of Taiwan to identify 73,597 patients who visited ambulatory care centers or were hospitalized with a first-time diagnosis of anxiety, affective disorders, or schizophrenia between 2001 and 2003 as the study cohort. We also randomly selected 220,791 enrollees matched with the study cohort for comparison. Each patient was individually tracked for 6 years to identify a subsequent PD diagnosis. Stratified Cox proportional hazard regressions were performed for the analysis.ResultsThe incidence rate of PD per 1000 person-years was 4.91 (95% confidence interval CI], 4.71–5.12) and 1.63 (95% CI, 1.56–1.70) for the psychiatric and comparison groups, respectively. Patients with psychiatric illnesses were more vulnerable to developing PD than nonpsychiatric individuals, exhibiting a 2.38-fold increased risk (95% CI, 2.23–2.53) after other covariates were considered. Furthermore, patients with schizophrenia exhibited the highest risk for developing PD.ConclusionsWe suggest effective monitoring of patients with psychiatric disturbances for potential long-term neurodegenerative diseases. |
| |
| Keywords: | Depression Anxiety Bipolar disorder Schizophrenia Parkinson disease |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
