三种经验性抗感染方案用于社区获得性肺炎的疗效及对患者炎症状态的影响

目的:探讨三种经验性抗感染方案用于社区获得性肺炎的临床疗效及对患者炎症状态的影响,以期为社区获得性肺炎寻找最佳治疗方案。方法:回顾性选取2018年沈阳医学院附属中心医院收治的社区获得性肺炎患者240例,根据治疗方案不同分为A、B及C组,每组80例。A组患者采用左氧氟沙星抗感染治疗,B组患者采用哌拉西林舒巴坦钠抗感染治疗,C组患者采用头孢地嗪钠抗感染治疗。观察三组患者的临床疗效、住院时间、不良反应发生情况及治疗前后炎症因子[超敏C反应蛋白(hs-CRP)、降钙素原(PCT)]水平。结果:A组患者的总有效率为97.50%(78/80),明显高于B组的91.25%(73/80)和C组的88.75%(71/80),差异均有统计学意义(P<0.05);B、C组患者总有效率的差异无统计学意义(P>0.05)。三组患者住院时间的差异均无统计学意义(P>0.05)。A、B及C组患者不良反应发生率分别为2.50%(2/80)、2.50%(2/80)及5.00%(4/80),不良反应均轻微,组间比较,差异均无统计学意义(P>0.05)。治疗后,三组患者hs-CRP、PCT水平均较治疗前明显改善,且A组患者明显低于B、C组,差异均有统计学意义(P<0.05)。结论:左氧氟沙星经验性治疗社区获得性肺炎的疗效更佳,可以明显改善患者的炎症状态。

Efficacy of Three Different Empirical Anti-Infection Programs in the Treatment of Patients with Community-Acquired Pneumonia and its Effects on Inflammatory State

OBJECTIVE:To probe into the clinical efficacy of three different empirical anti-infection programs in the treatment of patients with community-acquired pneumonia and its effects on inflammatory state,so as to provide reference for the optimized treatment for community-acquired pneumonia.METHODS:Totally 240 patients with community-acquired pneumonia admitted into Central Hospital Affiliated to Shenyang Medical College in 2018 were extracted to be divided into the group A,group B and group C via different treatment programs,with 80 cases in each group.The group A was treated with levofloxacin,the group B was given piperacillin sulbactam sodium,while the group C received cefodizime sodium.The clinical efficacy,length of stay,incidence of adverse drug reactions and levels of inflammatory factors[hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT)]before and after treatment of three groups were observed.RESULTS:The total effective rate of group A was 97.50%(78/80),significantly higher than that of group B[91.25%(73/80)]and group C[88.75%(71/80)],the difference was statistically significant(P<0.05);and there was no significant difference between group B and group C(P>0.05).There was no significant difference in the length of stay among three groups(P>0.05).The incidence of adverse drug reactions in group A,group B and group C was 2.50%(2/80),2.50%(2/80)and 5.00%(4/80),respectively,the adverse drug reactions of three groups were mild,without any significant difference(P>0.05).After treatment,the levels of hs-CRP and PCT in three groups were significantly improved compared with those before treatment,and the data in group A were significantly lower than those in groups B and group C,the differences were statistically significant(P<0.05).CONCLUSIONS:Levofloxacin is more effective in empirical treatment of community-acquired pneumonia and can significantly improve patient’s inflammatory state.