Bone mineral density and the risk of breast cancer: a case-control study of Korean women |
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| Affiliation: | 1. Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea;2. Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;3. Department of Family Medicine, Samsung Medical Center and Center for Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea;4. Health Care Center, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea;5. Department of Family Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea;6. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Victoria, Australia;7. Department of Epidemiology and Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, Korea;1. Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, PR China;2. The 96th Class, 7-Year Program, China Medical University, Shenyang 110001, Liaoning Province, PR China;3. Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang 110001, Liaoning Province, PR China;4. Institute of Pathology and Pathophysiology, China Medical University, Shenyang 110001, Liaoning Province, PR China;1. State Key Laboratory of Hydrology—Water Resources and Hydraulic Engineering, Hohai University, Nanjing 210098, PR China;2. College of Hydrology and Water Resources, Hohai University, Nanjing 210098, China;3. Department of Earth Sciences, Uppsala University, Uppsala, Sweden;4. Dongting Road No. 60, Hexi District, Tianjing, China;5. Yangzhou Hydrology and Water Resources Investigation Bureau,Yangzhou 225000, China;6. Department of Geology, United Arab Emirates University, Al Ain, UAE;7. Tandem Laboratory, Uppsala University, Uppsala, Sweden;8. Department of Aquatic Resources, Swedish Agricultural University, Oregrund, Sweden;9. Risø National Laboratory for Sustainable Energy, Technical University of Denmark, Roskilde, Denmark;10. Xi''an AMS center and SKLLQG Institute of Earth Environment, CAS, Xi''an 710075, China;11. Population Biology and Conservation Biology, Uppsala University, Uppsala, Sweden;1. Medical College of Nankai University, Tianjin, 300071, China;2. Department of Neurosurgery, Tianjin Huan Hu Hospital, Tianjin, 300060, China |
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| Abstract: | PurposeBone mineral density (BMD) may be useful as a surrogate marker reflecting lifetime exposure to estrogen in a woman. Our study aimed to investigate an association between BMD and breast cancer risk.MethodsA case-control study was conducted using 253 breast cancer cases and 506 age and menopausal status–matched controls from the same institution. Cases were ascertained through medical record review of the women with abnormal mammographic findings. BMD was measured at the lumbar spine and femoral neck using a dual-energy X-ray absorptiometry. The association was estimated by conditional logistic regression analysis with an adjustment for covariates.ResultsAlthough there was no difference in the association between pre- and postmenopausal disease, the association between BMD and breast cancer was evident for postmenopausal breast cancer. One standard deviation in age and menopausal status adjusted BMD at lumbar spine and femur neck was associated with 1.35-fold (standard error = 0.19, P = .04) and 1.34-fold (standard error = 0.20, P = .05) increased likelihood of breast cancer risk, respectively, for postmenopausal women.ConclusionAfter adjusting for covariates, higher BMD at lumbar spine and femur neck are associated with increased likelihood of breast cancer risk for postmenopausal women. These findings suggest that BMD could be included in breast cancer risk prediction models for postmenopausal Korean women. |
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| Keywords: | Breast neoplasm Case-control study Korean Bone density Menopause |
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