Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease |
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| Institution: | 1. Department of Endocrinology and Metabolism, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, 312000, China;2. Medicine and Bioscience College, Zhejiang University City College, Hangzhou, 310000, China;3. School of Food Science and Engineering, Zhejiang University, Hangzhou, 312029, China;1. Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan;2. Omachi Municipal General Hospital, Omachi, Japan;1. Department of Epidemiology, New England Research Institutes, Inc., Watertown, MA, USA;2. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA;1. Department of Nephrology, Medical University of Lublin, Lublin, Poland;2. Department of Cardiology, Medical University of Lublin, Lublin, Poland;1. The University of Michigan, Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Ann Arbor, MI;2. Eastern Michigan University, College of Health & Human Services, The Program of Health Administration, Ypsilanti, MI;3. The University of Michigan, Division of Pediatric Endocrinology, Child Health Evaluation and Research Unit, Ann Arbor, MI;4. The University of Michigan, Department of Epidemiology, Ann Arbor, MI |
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| Abstract: | AimsTo investigate the relationship between serum phospholipid omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD).Methods51 patients with T2DM and NAFLD (T2DM + NAFLD group), 50 with T2DM alone (T2DM group), 45 with NAFLD alone (NAFLD group), and 42 healthy control subjects (NC group) were studied. Serum ω-3 PUFA profiles were analyzed by gas chromatography, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and serum lipid concentrations were measured. Insulin resistance was assessed by the homeostasis model assessment method (HOMA-IR).ResultsHOMA-IR levels were higher in the T2DM + NAFLD group than in the T2DM, NAFLD and NC groups (p < 0.05), as were ALT, AST, GGT, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) concentrations (p < 0.05). Conversely, serum ω-3 PUFA levels were significantly lower in the T2DM + NAFLD group than in the other groups (p < 0.05). The ω-3 PUFA level was negatively correlated with HOMA-IR, TC, LDL-C and TG.ConclusionsSerum phospholipid ω-3 PUFA levels were significantly decreased in patients with T2DM and NAFLD, and were negatively related with insulin resistance. Thus, reduced ω-3 PUFAs may play an important role in the development of T2DM and NAFLD. |
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