磁共振氢质子波谱在下肢骨-软组织疾病中应用初探

目的 探讨磁共振氢质子波谱(^1HMRS)研究肢体骨-软组织疾病的可行性及其价值。资料与方法 对10例下肢正常骨、5例下肢正常肌肉、6例下肢良性骨病、11例下肢恶性骨肿瘤及1例下肢恶性横纹肌肉瘤进行^1HMRS测量，并采用单体素激发回波序列(SVS-STEAM)。结果 下肢骨-软组织疾病的^1HMRS波形与正常组织明显不同，良、恶性病变也存在差异，恶性病变的胆碱(Cho)含量明显升高。结论 ^1HMRS是无创性研究肢体骨-软组织疾病的生化及代谢变化的理想方法。

Preliminary Evaluation of 1 H MR Spectroscopy in Studying Bone and Soft Tissue Diseases of the Lower Limbs

Objective To discuss the feasibility and the clinical value of 1H MR spectroscopy (MRS) in studying bone and soft tissue diseases of the lower limbs.Materials and Methods 1H MRS was performed to study the lower limbs. The lower limbs of the subjects had normal skeleton (n=10), normal muscles (n=5), benign lesions (n=6), malignant bone tumor (n=11) or rhabdomyosarcoma (n=1). SVS-STEAM sequence was used.Results 1H MRS wave style of the diseased bone and soft-tissue was different from that of the normal ones, and the difference also existed between benign and malignant lesions. Choline level in malignant lesions was markedly higher than that in benign lesions.Conclusion 1H MRS is an ideal and noninvasive means for the study of biochemical and metabolic characteristics of bone and soft-tissue disorders of the limbs.