脑源性神经营养因子前体的研究进展

神经营养因子是一种分泌性多肽类生长因子家族,参与神经系统的多种生理功能活动,研究发现成熟的脑源性神经营养因子与其前体分子具有不同的生物学活性,它们的受体以及介导的细胞内信号通路也大相径庭。本文对近年来关于脑源性神经营养因子前体分子的研究进展予以综述,着重讨论其体内分布、生物合成与分泌、生物学活性以及与疾病的联系。研究脑源性神经营养因子前体分子在生理和病理状态下的作用将对未来的药物开发和神经系统疾病的治疗具有重要的意义。

Advancement in research on precursor of brain derived neurotrophic factor

The neurotrophins are a family of growth factors belong to a class of secreted proteins,which participate in several physiological events of neural system.Recent studies indicate that pro-neurotrophins and their mature forms often have opposite function in biological effects,their receptors and the intracellular signaling pathways.The recent progress of precursor of brain derived neurotrophic factor（proBDNF）,especially the distribution,biosynthesis,secretion,bioactivity of proBDNF and the relationship between proBDNF and neural system diseases are reviewed in this article.It is very important to study the function of proBDNF participated in the physiological and pathological conditions for drug researching and developing and for the treatment of nervous system diseases.