Investigational strategies in autologous stem cell transplantation for follicular lymphoma |
| |
Authors: | Oliver Weigert MD Martin Dreyling MD PhD Michael Unterhalt MD Wolfgang Hiddemann MD PhD Christian Buske MD |
| |
Institution: | (1) Department of Internal Medicine III, Ludwig-Maximilians-University, 15, 81377 Marchioninistrasse, Munich, Germany |
| |
Abstract: | Recent retrospective analyses indicate prolonged survival for patients with follicular lymphoma over the past 25 years, attributed
most likely to improved supportive care and sequential application of effective therapies. Encouraging results were obtained
from several randomized trials evaluating myeloablative therapy followed by autologous stem cell transplantation (ASCT) as
consolidation therapy applied to patients with advanced-stage follicular lymphoma either in first remission or as salvage
therapy. However, because of the successful introduction of rituximab to the standard therapeutic repertoire, with its long-term
beneficial clinical impact, ASCT must be reevaluated in prospective clinical trials, especially taking into account the potential
short- and long-term toxicity associated with high-dose therapy. The concept of in vivo purging before or after ASCT and the
introduction of radioimmunotherapy as part of the myeloablative regimen may further improve treatment results, reduce toxicity,
and increase applicability. Combination of these novel strategies into a multimodal approach justifies hope that the treatment
outcome of patients suffering from follicular lymphoma will be further improved. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|