帕夫林治疗强直性脊柱炎临床疗效观察

目的：评价帕夫林对强直性脊柱炎的疗效和安全性。方法：分为两组。治疗组30例，常规治疗＋帕夫林胶囊，每次2粒，每日3次，口服3个月。对照组30例，常规治疗＋安慰剂，每次2粒，每日3次，口服3个月。观察临床指标，安全评价，疗效评价。结果：治疗前后两组在外周关节痛、指地距离、BASFI 3项指标有显著性差异；治疗前后实验结果显示帕夫林对肝、肾功能及血象均无明显影响；治疗前后两组疗效比较，治疗组总有效率较对照组高，但两组间无显著性差异。两组不良反应都以消化系统灰主。治疗组不良反应发生率为16．7％，对照组不良反应发生率为13．3％，两组间无显著性差异。结论：帕夫林具有抗炎、镇痛、双向免疫调节作用。副作用少而轻，病人耐受性好，较安全。特别是对腱附着点炎方面的作用较其他药物似更有优点，单独用于治疗强直性脊柱炎还不能获得满意疗效，可长期作为辅助治疗与其他治疗药物联合应用于强直性脊柱炎。

Efficacy of TGP in the treatment of ankylosing spondylitis

Objective To evaluate the efficacy and safeness of TGP in the treatment of ankyolsing spondylitis (AS).Methods The randomized,double blind trial was used for three months.All patients were randomly divided into two groups:treatment group(TG) with 30 subjects(normal treatment plus TGP,the dose of TGP:3 tablest of each time,third daily);Control group(CG) with 30 subjects(normal treatment plus placebo,2 tablets of each time,third daily).Results Before and after treatment,the three index of peripheral joint pain,BASFL,fingertip to floor were significant difference between two groups;The test results indicated that TGP had no significant effect on the function of liver and kidney,blood picture;The efficient rate of overall assessment in TG was higher than that in CG,but there were not significant difference between the two groups.The main side effect in the two groups was digestive system symptom,the occurrence rate of side effect in TG was 16.7%,CG was 13.3%,there were not significant difference between two groups.Conclusion TGP has the effect on anti inflammatory,analgesic,double immune regulation.Side effects are less and slight.The patients have better tolerated to TGP.Especially to muscle pain,TGP seems to be more advantage than other drugs.TGP can be a long term to combine with other drugs to treat AS as adujvant therapy.