| 帕立骨化醇对糖尿病大鼠肾脏保护作用的机制探讨 |
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| 引用本文： | 邹敏书,余健,聂国明,阿威逊,罗莉漫,徐洪涛. 帕立骨化醇对糖尿病大鼠肾脏保护作用的机制探讨[J]. 解放军药学学报, 2011, 27(6): 475-479. DOI: 10.3969/j.issn.1008-9926.2011.06.02 |
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| 作者姓名： | 邹敏书 余健 聂国明 阿威逊 罗莉漫 徐洪涛 |
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| 作者单位： | 1. 广州军区武汉总医院儿科,湖北武汉,430070
2. 上海交通大学附属上海儿童医院肾脏科,上海,200040 |
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| 摘 要： | 目的 观察维生素D受体激动剂帕立骨化醇对糖尿病大鼠肾脏保护作用的可能机制.方法 雄性Wistar大鼠随机分为对照组、糖尿病组、糖尿病组+帕立骨化醇治疗组.大鼠建立糖尿病模型.第10周测肾质量/体质量、空腹血糖、24h尿微量白蛋白排泄率；肾组织匀浆测定丙二醛含量、超氧化物歧化酶活性；RT-PCR检测肾组织肾素受体、nep...
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| 关 键 词： | 帕立骨化醇 糖尿病 肾素受体 nephrin 核因子-κB |
Renoprotective Mechanism of Paricalcitol in Diabetic Rats |
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| ZOU Min-shu,YU Jian,NIE Guo-ming,HE Wei-xun,LUO li-man,XU Hong-tao. Renoprotective Mechanism of Paricalcitol in Diabetic Rats[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2011, 27(6): 475-479. DOI: 10.3969/j.issn.1008-9926.2011.06.02 |
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| Authors: | ZOU Min-shu YU Jian NIE Guo-ming HE Wei-xun LUO li-man XU Hong-tao |
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| Affiliation: | 1Department of Pediatrics, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China ; 2Deparment of Nephrology, Affiliated Children＇s Hospital of Shanghai Jiaotong University,Shanghai 200040,China |
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| Abstract: | Objective To investigate the renoprotective mechanism of vitamin D receptor agonist paricalcitol in diabetic rats.Methods Male Wistar rats were randomly divided into three groups:control,diabetes and paricalcitol-treatment.Diabetes in rats was induced by intraperitoneal administration of streptozotocin(60 mg/kg).At 10 weeks,and kidney weight/body weight,blood glucose(BG),the 24-hour urinary albumin excretion rate(UAER),and the content of malondialdehyde(MDA) and activity of superoxide dismutase(SOD) in rena... |
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| Keywords: | paricalcitol diabetes renin receptor nephrin nuclear factor-kappa B |
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