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| 骨髓间充质干细胞治疗急性腹膜纤维化的作用方式探讨 | |
| 引用本文： | 王楠,张利,李清刚,胡婕,李典耕,师锁柱,傅博,陈香美.骨髓间充质干细胞治疗急性腹膜纤维化的作用方式探讨[J].解放军医学杂志,2011,36(12):1263-1268. |
| 作者姓名： | 王楠 张利 李清刚 胡婕 李典耕 师锁柱 傅博 陈香美 |
| 作者单位： | 1. 南开大学医学院 2. 100853,北京 解放军总医院肾内科 3. 030001,太原 山西医科大学七年制临床医学专业 |
| 基金项目： | 国家重点基础研究发展(973)计划(2011CB964904); 国家高技术研究发展(863)计划(2011AA020115) |
| 摘 要： | 目的 探讨骨髓间充质干细胞(MSCs)治疗急性腹膜纤维化的作用方式.方法 取SD大鼠114只,制作急性膜腹粘连模型,其中6只在腹膜刮伤后24h经尾静脉(n=3)或腹腔(n=3)注入MS(s,采用活体成像示踪法观察MSCs的分布并对两种方式注射后MSCs的示踪效果进行比较；其余108只大鼠随机分为无血清条件培养基(CM)... |
| 关 键 词： | 干细胞 细胞移植 腹膜 损伤 纤维化 条件培养基 |
Study on functional mode of marrow mesenchymal stem cells to acute peritoneal fibrosis |
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| WANG Nan , ZHANG Li , LI Qing-gang , HU Jie , LI Dian-geng , SHI Suo-zhu , FU Bo , CHEN Xiang-mei.Study on functional mode of marrow mesenchymal stem cells to acute peritoneal fibrosis[J].Medical Journal of Chinese People's Liberation Army,2011,36(12):1263-1268. | |
| Authors: | WANG Nan ZHANG Li LI Qing-gang HU Jie LI Dian-geng SHI Suo-zhu FU Bo CHEN Xiang-mei |
| Institution: | WANG Nan,ZHANG Li,LI Qing-gang,HU Jie,LI Dian-geng,SHI Suo-zhu,FU Bo,CHEN Xiang-mei.Department of Nephrology,General Hospital of PLA,Beijing 100853,China |
| Abstract: | Objective The current study was designed to investigate the functional mode of mesenchymal stem cells(MSCs) to exert the therapeutic effects on acute peritoneal fibrosis.Methods A total of 114 SD Rats were taken to make acute peritoneal adhesion models.Among which,six rats were injected with MSCs through the caudal vein(n=3) or abdominal cavity(n=3) 24 h after peritoneal scraping injury.The distribution of MSCs after injection was tracked by in vivo imaging,and the tracing effects of MSCs after two kinds of... |
| Keywords: | stem cells cell transplantation peritoneum wounds and injuries fibrosis conditioned culture medium |
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