| 氩氦刀冷冻消融治疗乙型肝炎病毒相关性肝细胞癌前后PD-1的变化及其与预后的关系 |
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| 引用本文： | 周霖,曾珍,石峰,张敏娜,陈艳,常秀娟,陆荫英,白文林,曲建慧,王春平,王宏,楼敏,王福生,吕吉云,杨永平.氩氦刀冷冻消融治疗乙型肝炎病毒相关性肝细胞癌前后PD-1的变化及其与预后的关系[J].解放军医学杂志,2011,36(10):1031-1036. |
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| 作者姓名： | 周霖 曾珍 石峰 张敏娜 陈艳 常秀娟 陆荫英 白文林 曲建慧 王春平 王宏 楼敏 王福生 吕吉云 杨永平 |
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| 作者单位： | 1. 100039,北京 解放军302医院肝癌治疗研究中心
2. 全军传染病研究所 |
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| 基金项目： | 国家科技重大专项课题(2008ZX10002-018); 首都医学发展基金课题(2007-1021,2009-2041) |
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| 摘 要： | 目的 观察氩氦冷冻消融治疗对乙型肝炎病毒相关性肝细胞癌(HCC)患者外周血细胞程序性死亡受体-1(PD-1)表达的影响,分析PD-1与HCC病程及患者预后的关系.方法 收集2006年1月-2009年1月收治的乙型肝炎病毒相关性HCC患者141例,其中男109例,女32例,年龄28～71岁,巴塞罗那分期(BCLC)早期4...
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| 关 键 词： | 程序性死亡受体-1 癌 肝细胞 冷冻外科手术 预后 |
Changes in PD-1 and effect thereof on prognosis of patient after argon-helium cryoablation for hepatitis B related-hepatocellular carcinoma |
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| ZHOU Lin,ZENG Zhen,SHI Feng,ZHANG Min-na,CHEN Yan,CHANG Xiu-juan,LU Yin-ying,BAI Wen-lin,QU Jia-hui,WANG Chun-ping,WANG Hong,LOU Min,WANG Fu-sheng,LV Ji-yun,YANG Yong-ping.Changes in PD-1 and effect thereof on prognosis of patient after argon-helium cryoablation for hepatitis B related-hepatocellular carcinoma[J].Medical Journal of Chinese People's Liberation Army,2011,36(10):1031-1036. |
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| Authors: | ZHOU Lin ZENG Zhen SHI Feng ZHANG Min-na CHEN Yan CHANG Xiu-juan LU Yin-ying BAI Wen-lin QU Jia-hui WANG Chun-ping WANG Hong LOU Min WANG Fu-sheng LV Ji-yun YANG Yong-ping |
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| Institution: | ZHOU Lin,ZENG Zhen,SHI Feng,ZHANG Min-na,CHEN Yan,CHANG Xiu-juan,LU Yin-ying,BAI Wen-lin,QU Jian-hui,WANG Chun-ping,WANG Hong,LOU Min,WANG Fu-sheng,LV Ji-yun,YANG Yong-ping.Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing 100039,China |
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| Abstract: | Objective To investigate the relationship of the expression of circulating programmed death-1(PD-1) to the disease course of hepatocellular carcinoma(HCC),to explore the influence of cryoablation on the changes in PD-1 in peripheral blood,and to analyze the correlation between PD-1 and the prognosis of HCC patients.Methods The expression of circulating PD-1 was determined by flow cytometry to analyze the correlation between the expressions of PD-1 and progression of HCC.Of 141 patients with HCC,109 underwen... |
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| Keywords: | programmed death-1 carcinoma hepatocellular cryosurgery prognosis |
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