| 非水毛细管电泳法测定胃肠宁片中巴马汀小檗碱和药根碱含量 |
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| 引用本文： | 卢日刚,张琳婧.非水毛细管电泳法测定胃肠宁片中巴马汀小檗碱和药根碱含量[J].解放军药学学报,2011,27(6):521-523. |
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| 作者姓名： | 卢日刚 张琳婧 |
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| 作者单位： | 广西食品药品检验所,广西南宁,530021 |
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| 摘 要： | 目的 建立非水毛细管电泳法同时测定胃肠宁片中巴马汀、小檗碱和药根碱的含量.方法 以75 mmol/L醋酸铵甲醇溶液(pH 6.5)为电泳介质,运行电压15 kV,压力进样5s,柱温25℃,检测波长260 nm.结果 该方法能使3种药物在16 min内得到完全分离,巴马汀、小檗碱和药根碱分别在1.494～19.92 mg...
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| 关 键 词： | 非水毛细管电泳法 巴马汀 小檗碱 药根碱 |
Determination of Palmatine Berberine and Jatrorrhizine in Weichangning Tablets By Non-aqueous Capillary Electrophoresis |
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| LU Ri-gang,ZHANG Lin-jing.Determination of Palmatine Berberine and Jatrorrhizine in Weichangning Tablets By Non-aqueous Capillary Electrophoresis[J].Pharmaceutical Journal of Chinese People's Liberation Army,2011,27(6):521-523. |
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| Authors: | LU Ri-gang ZHANG Lin-jing |
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| Institution: | LU Ri-gang,ZHANG Lin-jing Guangxi Institute for Food and Drug Control,Nanning 530021,China |
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| Abstract: | Objective To establish a non-aqueous capillary electrophoresis method for the separation and determination of palmatine, berberine and jatrorrhizine in Weichangning Tablets. Methods The runing buffer was 75 mmol/L ammonium acetate （pH 6.5 ） ,the running voltage was 15 kV. The detection temperature was 25℃and the detection wavelength was set at 260 nm. Results Linearity was obtained over the range of 1. 494-19.92 mg/L（ r = 0.9994）for palmatine,l.485-19.8 mg/L （ r =0.9990） for berberine and 1.53-20.35 mg/L（ r =0.9995） for jutrorrhizine. The average recovery was 99.4% （RSD = 0.4% ） for palmatine, 100.5% （RSD = 0.6% ） for berberine and 101.4% （RSD = 0.3% ） for jatrorrhizine, respectively. Conclusion This method is simple, rapid and reproducible. It is successfully employed for the determination of palmatine, berberine and jatrorrhizine in Weichangning Tablets. |
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| Keywords: | non-aqueous capillary electrophoresis palmatine berberine jatrorrhizine |
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