| 胶质细胞活化在大鼠蛛网膜下腔出血后早期脑损伤中的作用 |
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| 引用本文： | 罗春霞,易斌,陈渝杰,李博,唐卫华,刘智,陈志,朱刚,冯华.胶质细胞活化在大鼠蛛网膜下腔出血后早期脑损伤中的作用[J].解放军医学杂志,2011,36(12):1348-1350. |
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| 作者姓名： | 罗春霞 易斌 陈渝杰 李博 唐卫华 刘智 陈志 朱刚 冯华 |
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| 作者单位： | 1. 400038,重庆 第三军医大学西南医院神经外科
2. 400038,重庆 第三军医大学西南医院麻醉科 |
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| 基金项目： | 国家自然科学基金(81070931,30973101,30801186); 重庆市自然科学基金(2009BB5158) |
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| 摘 要： | 目的 观察大鼠蛛网膜下腔出血(SAH)后胶质细胞的活化情况,探讨SAH早期脑损伤的机制.方法 雄性SD大鼠24只,随机分为SAH组和假手术组,每组12只.SAH组采用颈内动脉线栓穿刺法建立SAH模型,于建模后24h检测神经功能缺损情况,假手术组不建模,处死大鼠,测定脑含水量,并采用免疫荧光组织化学染色观察小胶质细胞(以...
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| 关 键 词： | 蛛网膜下腔出血 脑损伤 小神经胶质细胞 星形细胞 |
Effect of glial activation on early brain injury after subarachnoid hemorrhage in rats |
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| LUO Chun-xia
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YI Bin
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HEN Yu-jie
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LI Bo
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TANG Wei-hua
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LIU Zhi
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CHEN Zhi
,
ZHU Gang
,
FENG Hua.Effect of glial activation on early brain injury after subarachnoid hemorrhage in rats[J].Medical Journal of Chinese People's Liberation Army,2011,36(12):1348-1350. |
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| Authors: | LUO Chun-xia YI Bin HEN Yu-jie LI Bo TANG Wei-hua LIU Zhi CHEN Zhi ZHU Gang FENG Hua |
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| Institution: | LUO Chun-xia,YI Bin,CHEN Yu-jie,LI Bo,TANG Wei-hua,LIU Zhi,CHEN Zhi,ZHU Gang,FENG Hua.Department of Neurosurgey,Southwest Hospital,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | Objective The activation of the glial cells of rats after subarachnoid hemorrhage(SAH) was observed in the current study to determine the mechanism of early brain injury after SAH.Methods Twenty-four male SD rats were randomly divided into two groups,namely,the SAH(n=12) and sham-operated control(n=12) groups.The internal carotid arteries of the rats in the SAH group were punctured using a suture needle,and the neurological defect was inspected after 24 h.The rats were then killed to measure their brain wat... |
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| Keywords: | subarachnoid hemorrhage brain injuries microglia astrocytes |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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