| 丹参多酚酸盐对小鼠肝脏缺血再灌注后肺损伤的保护作用 |
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| 引用本文： | 滕飞,傅志仁,孙克彦,郭闻渊,刘芳,王正昕,丁国善.丹参多酚酸盐对小鼠肝脏缺血再灌注后肺损伤的保护作用[J].解放军医学杂志,2011,36(11):1171-1174. |
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| 作者姓名： | 滕飞 傅志仁 孙克彦 郭闻渊 刘芳 王正昕 丁国善 |
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| 作者单位： | 200003,上海 第二军医大学长征医院器官移植中心 |
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| 基金项目： | 国家自然科学基金(30772045); 上海市卫生局青年科研项目(2008Y085) |
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| 摘 要： | 目的 研究丹参多酚酸盐对小鼠肝脏缺血再灌注后肺损伤的保护作用及其机制.方法 24只C57BL/6小鼠随机分为假手术组、对照组和丹参多酚酸盐组,每组8只.假手术组小鼠仅接受麻醉、开腹及关腹操作；丹参多酚酸盐组及对照组小鼠建立肝脏90min缺血再灌注模型,缺血前丹参多酚酸盐组小鼠经尾静脉注射丹参多酚酸盐60mg/kg,对照...
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| 关 键 词： | 丹参多酚酸盐 肝脏 再灌注 呼吸窘迫综合征 成人 炎症 |
Protective effect of salvianolate on lung injury induced by ischemia reperfusion injury of liver in mice |
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| TENG Fei,FU Zhi-ren,SUN Ke-yan,GUO Wen-yuan,LIU Fang,WANG Zheng-xin,DING Guo-shan.Protective effect of salvianolate on lung injury induced by ischemia reperfusion injury of liver in mice[J].Medical Journal of Chinese People's Liberation Army,2011,36(11):1171-1174. |
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| Authors: | TENG Fei FU Zhi-ren SUN Ke-yan GUO Wen-yuan LIU Fang WANG Zheng-xin DING Guo-shan |
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| Institution: | TENG Fei,FU Zhi-ren,SUN Ke-yan,GUO Wen-yuan*,LIU Fang,WANG Zheng-xin,DING Guo-shan.Organ Transplantation Center,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China |
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| Abstract: | Objective To evaluate the protective effect of salvianolate on lung injury induced by hepatic ischemia reperfusion(IR) injury in mice and its underlying mechanisms.Methods A hepatic IR model of mice was reproduced,and 24 animals were assigned into 3 groups(8 each): sham operation(SO) group,control group and salvianolate(SV) group.Just before ischemia induction,animals in SV group received salvianolate injection at a dose of 60 mg/kg via tail vein,while in control group the mice received normal saline with a... |
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| Keywords: | salvianolate liver reprfusion respiratory distress syndrome adult inflammation |
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