| AT2受体对自发性高血压大鼠肾脏近曲小管上皮细胞AT1受体表达与功能的影响 |
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| 引用本文： | 杨剑,任红梅,孙海岚,陈新建,何多芬,蒋宝泉,周林,曾春雨. AT2受体对自发性高血压大鼠肾脏近曲小管上皮细胞AT1受体表达与功能的影响[J]. 解放军医学杂志, 2011, 36(11): 1163-1166 |
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| 作者姓名： | 杨剑 任红梅 孙海岚 陈新建 何多芬 蒋宝泉 周林 曾春雨 |
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| 作者单位： | 1. 400042,重庆 第三军医大学大坪医院心血管病专科医院心内科、重庆心血管病研究所
2. 400042,重庆 第三军医大学大坪医院营养科 |
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| 基金项目： | 国家杰出青年科学基金(30925018); 重庆市杰出青年科学基金(CSTC2009BA5044); 第三军医大学科研创新基金(2009XQN42) |
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| 摘 要： | 目的 研究AT2受体激动剂CGP42112对自发性高血压大鼠(SHR)肾脏近曲小管上皮(RPT)细胞AT1受体的表达及功能的影响.方法 以RPT细胞株作为研究对象,采用不同浓度AT2受体激动剂CGP42t12(10-9～10-7mol/L)作用24h或同一浓度CGP42112(10-7mol/L)作用不同时间(8、16...
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| 关 键 词： | AT2受体 AT1受体 自发性高血压大鼠 肾脏近曲小管上皮细胞 |
Effect of AT_2 receptor on AT_1 receptor expression and function in epithelial cells of renal proximal tubule of spontaneously hypertensive rats |
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| YANG Jian,REN Hong-mei,SUN Hai-lan,CHEN Xin-jian,HE Duo-fen,JIANG Bao-quan,ZHOU Lin,ZENG Chunyu. Effect of AT_2 receptor on AT_1 receptor expression and function in epithelial cells of renal proximal tubule of spontaneously hypertensive rats[J]. Medical Journal of Chinese People's Liberation Army, 2011, 36(11): 1163-1166 |
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| Authors: | YANG Jian REN Hong-mei SUN Hai-lan CHEN Xin-jian HE Duo-fen JIANG Bao-quan ZHOU Lin ZENG Chunyu |
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| Affiliation: | YANG Jian,REN Hong-mei,SUN Hai-lan,CHEN Xin-jian,HE Duo-fen,JIANG Bao-quan,ZHOU Lin,ZENG Chunyu*.Department of Cardiology,Daping Hospital,Third Military Medical University,Chongqing 400042,China |
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| Abstract: | Objective To examine the effect of AT2 receptor agonist CGP42112 on the expression and function of AT1 receptor in the epithelial cells of the renal proximal tubule(RPT) of spontaneously hypertensive rats(SHRs).Methods The present study investigated RPT cell strains and adopted different concentrations of AT2 receptor agonist CGP42112(10-9mol/L to 10-7mol/L) to act for 24h or the same concentration of CGP42112(10-7mol/L) to act for different periods(8,16,and 24h).The protein and mRNA expression of AT1 recep... |
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| Keywords: | AT2 receptor AT1 receptor Spontaneous hypertensive rat Renal proximal tubule cells |
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