肝局灶性结节状增生的临床病理学观察

目的观察肝局灶性结节状增生(FNH)的临床及病理学特点。方法收集解放军总医院1989年2月-2010年10月手术切除的FNH标本36例,均经4%甲醛溶液固定,石蜡包埋切片,行HE染色及CD34、CK免疫组化染色(SP法),光镜下观察其组织病理形态。结果 36例患者中男10例,女26例,平均年龄36.1岁;34例呈单发结节,2例呈多发结节;结节直径1.7~20.0cm,平均6.8cm;临床及影像学缺少特异性表现。组织形态学观察显示36例FNH中6例为血管扩张型,25例为经典型,3例为混合型,2例为肝细胞不典型增生型。病理学表现为结节状肿块,中央为纤维性瘢痕,其内为大小不等厚壁血管。免疫组化染色CD34及CK均呈阳性。经典型FNH具有4种特征性形态学表现,即肿瘤结节中央有星状瘢痕、异常结节状结构、畸形血管和毛细胆管增生。结论 FNH的病因可能与病灶处局部血液循环障碍有关。

Clinicopathologic analysis of 36 cases of focal nodular hyperplasia of the liver

Objective To study the clinical and pathologic features of focal nodular hyperplasia(FNH) of the liver.Methods Thirty-six surgical specimens of FNH collected from February 1989 to October 2010 in the General Hospital of PLA were used in the present study.The 36 formalin-fixed,paraffin-embedded surgical resection specimens were analyzed by hematoxylin-eosin(H-E)-staining and immunohistochemistry for CD34 and CK.The pathological changes were observed under light microscope.Results Of the 36 cases,10 were male...