| 高效液相色谱法测定阿德福韦酯片中阿德福韦酯的含量 |
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| 引用本文： | 易毛,韩晋,吴素体,刘峰群,李正明,郑绯,丁晋彪,王迪杰,杜成德. 高效液相色谱法测定阿德福韦酯片中阿德福韦酯的含量[J]. 解放军药学学报, 2011, 27(6): 529-531. DOI: 10.3969/j.issn.1008-9926.2011.06.020 |
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| 作者姓名： | 易毛 韩晋 吴素体 刘峰群 李正明 郑绯 丁晋彪 王迪杰 杜成德 |
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| 作者单位： | 1. 解放军302医院药学部,北京,100039
2. 山东世博金都药业有限公司,山东淄博,255086 |
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| 摘 要： | 目的 建立高效液相色谱法测定阿德福韦酯片中阿德福韦酯含量的方法.方法 采用高效液相色谱法测定阿德福韦酯的含量,流动相:乙腈-水(含1％三乙胺,磷酸二氢钾50 mmol/L,磷酸调pH至3.0)(40:60)；检测波长:260 nm；流速:1.0 ml/min；柱温:室温.结果 阿德福韦酯浓度在4.04 ～50.50 μ...
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| 关 键 词： | 高效液相色谱法 阿德福韦酯片 抗病毒药 |
Determination of Adefovir Dipivoxil in Adefovir Dipivoxil Tablets by High Performance Liquid Chromatography |
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| YI Mao,HAN Jin,WU Su-ti,LIU Feng-qun,LI Zheng-ming,ZHENG Fei,DING Jin-biao,WANG Di-jie,DU Cheng-de. Determination of Adefovir Dipivoxil in Adefovir Dipivoxil Tablets by High Performance Liquid Chromatography[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2011, 27(6): 529-531. DOI: 10.3969/j.issn.1008-9926.2011.06.020 |
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| Authors: | YI Mao HAN Jin WU Su-ti LIU Feng-qun LI Zheng-ming ZHENG Fei DING Jin-biao WANG Di-jie DU Cheng-de |
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| Affiliation: | Department of Pharmacy, Hospital 302 of PLA, Beijing 100039, China; Shandong Shibojindu Pharmaceutical Corporation Ltd,Zibo 255086, China |
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| Abstract: | Objective To develop an high performance liquid chromatography method for the determination of adefovir dipivoxil in adefovir dipivoxil tablets. Methods The chromatographic equipment includeds pump HPllO0, inspection instrument HPll00, chemical analytical station HP,and a mobile phase composed of acetoni- trile-water（40： 60） solution with 1% triethylamine and 50 mmoL/L potassium dihydrogen phosphate （ adjusted to pH 3.0 by phosphoric acid）. The flow rate was 1.0 mL/min and monitered at 260 nm. The column temperature was room temperature. Results The calibration curves of adefovir dipivoxil showed a good linear relation over the range of 4.04-50.50 μg/ml（ r =0. 9999）. The average recovery of adefovir dipivoxil was 99.77% and RSD was 0.24%. Conclusion This method is simple, accurate and with good reproducibility. It can be used for the determi- nation of adefovir dipivoxil in adefovir dipivoxil tablets. |
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| Keywords: | high performance liquid chromatography adefovir dipivoxil tablets antiviral agents |
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