| 脂蛋白对实验变态反应性脑脊髓炎的阻断研究 |
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| 引用本文： | 耿同超,山村隆,田平武.脂蛋白对实验变态反应性脑脊髓炎的阻断研究[J].中国神经免疫学和神经病学杂志,1994,1(1):14-18. |
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| 作者姓名： | 耿同超 山村隆 田平武 |
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| 作者单位： | 北京中日友好医院神经科，日本东京国立神经研究所 |
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| 基金项目： | 日本国际协力事业团资助 |
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| 摘 要： | 腹腔注射脂蛋白（ＰＬＰ）进行免疫耐受诱导，可保护小鼠既不发生ＰＬＰ引起的主动性实验变态反应性脑脊髓炎（ＥＡＥ）又不发生ＰＬＰ特异性淋巴细胞引起的被动性ＥＡＥ。提示在ＥＡＥ发病过程中，ＰＬＰ较髓鞘硷性蛋白（ＭＢＰ）更具作用。免疫耐受的机理可能为非胸腺依赖性且与非特异性免疫有一定关系。
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| 关 键 词： | 脂蛋白，免疫耐受，实验变态反应性脑脊髓炎 |
Blocking of Proteolipid (PLP)-induced Experimental Allergic Encephalomyelitis in Mice with PLP Peptide Used as Tolerogen |
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| Geng Tongchao,Takashi Yamamura,Takeshi Tabira.Blocking of Proteolipid (PLP)-induced Experimental Allergic Encephalomyelitis in Mice with PLP Peptide Used as Tolerogen[J].Chinese Journal of Neuroimmunology and Neurology,1994,1(1):14-18. |
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| Authors: | Geng Tongchao Takashi Yamamura Takeshi Tabira |
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| Abstract: | Immunotolerance in mice was induced by intraperitoneal injection of synthetic proteolipid (PLP) peptide.It completely prevented the development of PLP-induced active experimental allergic encephalomyelitis (EAE) and passive EAE and suggested that PLP may play a dominant role in EAE pathogenesis.The mechanism of tolerance may be independent of the thymus and involved the non-specific immune system.. |
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| Keywords: | proteolipid tolerance experimental allergic encephalomyelitis |
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