| 精氨酸加压素（AVP）的衍生物AVP4—8不能作用于AVPV1a受体而诱发电流反应 |
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| 引用本文： | 包永德,蒋晓鸣.精氨酸加压素（AVP）的衍生物AVP4—8不能作用于AVPV1a受体而诱发电流反应[J].中国神经科学杂志,1994,1(2):7-12. |
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| 作者姓名： | 包永德 蒋晓鸣 |
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| 作者单位： | 中国科学院上海生理研究所，中国科学院上海生物化学研究所 |
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| 摘 要： | 在微量注射大量肝脏ｍＲＮＡ之后，通过电压箝方法进行功能鉴定，两栖类卵母细胞成功地表达了ＡＶＰＶ１ａ受体。但在灌流ＡＶ４－８溶液时，却不能诱导卵母细胞产生内向振荡电流反应。提示ＡＶＰ４－８不能通过ＡＶＰＶ１ａ受体而介导生理学效应。
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| 关 键 词： | 两栖类 卵母细胞 精氨酸加压素 受体 mRNA表达 |
AVP_(4-8) CAN NOT ELICIT INWARD CURRENT RESPONSE THROUGH AVP V_(1a) RECEPTOR EXPRESSED IN AMPHIBIAN OOCYTES AFTER INJECTION OF RAT LIVER mRNA |
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| Bao Yong-de,Zhu Xing Jiang,Xiao Ming,Du Yu-cang.AVP_(4-8) CAN NOT ELICIT INWARD CURRENT RESPONSE THROUGH AVP V_(1a) RECEPTOR EXPRESSED IN AMPHIBIAN OOCYTES AFTER INJECTION OF RAT LIVER mRNA[J].Neuroscience Bulletin,1994,1(2):7-12. |
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| Authors: | Bao Yong-de Zhu Xing Jiang Xiao Ming Du Yu-cang |
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| Abstract: | The AVP V1a receptors can be expressed and functionally identified by the voltage-clamp method in amphibian oocytes after injection of rat liver mRNA.AVP4-8 is a segment of AVP and improve learning and memory markedly in the rat. This work is to investigats the action of AVP4-8 on the V1a receptors in oocytes. When AVP4-8 was bath-applied to the oocytes,no inward membrane current could be elicited. The data showed that AVP4-8 can not mediate physiological effect through AVP V1a receptors. |
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| Keywords: | AVP AVP4-8 amphibian oocyte mRNA expression rat liver |
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