Clinical update on phosphodiesterase type-5 inhibitors for erectile dysfunction |
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Authors: | Alberto Briganti Andrea Salonia Federico Deho’ Giuseppe Zanni Luigi Barbieri Patrizio Rigatti Francesco Montorsi |
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Institution: | (1) Department of Urology, Universitá Vita-Salute San Raffaele, Milan, Italy;(2) Cattedra di Urologia, Universitá Vita-Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy |
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Abstract: | Erectile dysfunction (ED) affects the sexual lives of millions of men. The first-line oral pharmacotherapy for most ED patients
is phosphodiesterase type-5 (PDE-5) inhibitors, of which three are available. Sildenafil is the most widely prescribed oral
agent for ED and has a very satisfactory efficacy–safety profile in all patient categories. Tadalafil and vardenafil were
introduced in the European Union and in the United States in 2003 and 2004, respectively. The three PDE-5 inhibitors share
many pharmacological and clinical characteristics, and each has unique features. This review, which is based on the contemporary
literature on PDE-5 inhibitors, describes the chemical, pharmacological, and clinical features of sildenafil, vardenafil,
and tadalafil. The first section reviews the pathophysiology of penile erection and PDE-5 inhibitor pharmacology. The second
section summarizes data regarding efficacy and safety of the three drugs in treating ED in the general population as well
as in selected patient categories. |
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Keywords: | Erectile dysfunction Phosphodiesterase type-5 inhibitors Sildenafil Tadalafil Vardenafil |
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