单磷酸阿糖腺苷联合布地奈德治疗小儿毛细支气管炎的临床研究

目的探讨单磷酸阿糖腺苷联合布地奈德治疗小儿毛细支气管炎的临床疗效。方法选取2014年9月—2016年9月沈阳医学院附属中心医院儿科收治的毛细支气管炎患者151例,随机分成对照组(75例)和治疗组(76例)。对照组雾化吸入吸入用布地奈德混悬液,0.5 mg加入生理盐水3 m L,1次/d,10 min/次。治疗组在对照组的基础上静脉滴注注射用单磷酸阿糖腺苷,0.1 g加入5%葡萄糖溶液100 m L中,1次/d。所有患者均治疗1周。观察两组患者临床效果,对比两组治疗前后症状消失时间、住院时间、炎性指标以及不良反应情况。结果治疗后,对照组和治疗组总有效率分别为84.00%和96.05%,两组总有效率比较差异具有统计学意义(P0.05)。治疗后,治疗组患儿的退热时间、湿啰音消失时间、喘息消失时间和咳嗽消失时间以及住院时间均明显短于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患儿肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)以及IL-8指标均明显降低(P0.05);且治疗组的降低程度明显优于对照组,两组比较差异有统计学意义(P0.05)。结论单磷酸阿糖腺苷联合布地奈德治疗小儿毛细支气管炎,在临床症状消失时间、住院时间以及炎症因子水平改善方面上均优于单独使用布地奈德治疗,具有一定的临床推广应用价值。

Clinical study on vidarabine monophosphate combined with budesonide in treatment of children with bronchiolitis

Objective To investigate the influence of ziprasidone combined with amend electric shock on the efficacy and metabolism of patients with first-episode schizophrenia.Methods According to random number table, 86 cases with first-episode schizophrenia from July 2013 to July 2016 in the Second Affiliated Hospital of Xinxiang Medical University were chosen and divided into observation group and control group. The patients in observation group were given ziprasidone combined with first-episode schizophrenia, the patients in control group were taken with olanzapine combined with first-episode schizophrenia. The PANSS total score, CGI score, total efficacy, adverse reaction, body mass index, glycometabolism, and lipid metabolism of two groups were observed and compared.Results The PANSS score, CGI score of two groups were all obvious decreased, which had no significant difference, the total efficacy of two groups had no significant difference; The TESS scores were all decreased, and the TESS score of observation group was obviously lower than that of control group (P<0.05). Compared with before treatment, the BMI, fasting blood sugar, triglyceride, total cholesterol, high/low density lipoprotein and fasting insulin level of observation group after treatment had no obvious significant difference, while the BMI, fasting blood sugar, triglyceride, total cholesterol, low density lipoprotein, and fasting insulin levels of control group had obvious significant difference, and the BMI, fasting blood sugar, triglyceride, total cholesterol, and fasting insulin of observation group were obviously lower than control group (P<0.05).Conclusion Olanzapine and ziprasidone combined with amend electric shock have obvious efficacy on patients with first-episode schizophrenia, while the ziprasidone had lower adverse reaction and metabolic side effects, which is worth of clinical promotion and application.