托莫西汀和阿立哌唑治疗儿童注意缺陷多动障碍的疗效比较

目的比较托莫西汀和阿立哌唑治疗儿童注意缺陷多动障碍的临床疗效。方法收集2015年1月—2016年1月在大连市第七人民医院诊治的88例注意缺陷多动障碍患者,根据用药方案的不同分为对照组和治疗组,每组各44例。对照组患儿口服阿立哌唑片,1片/次,每晚1次。治疗组患儿口服盐酸托莫西汀胶囊,初始剂量为每天0.5 mg/kg,治疗过程中根据临床反应及耐药性进行剂量调整,每天最大剂量为1.4 mg/kg。两组患儿均连续治疗6周。比较两组患儿临床效果、SNAP-IV量表评分、数字划消失误率和Conners父母量表测验结果。结果治疗后,对照组和治疗组的总有效率分别为81.82%、97.73%,两组总有效率比较差异具有统计学意义(P0.05)。治疗后,两组患儿SNAP-IV量表评分、数字划消失误率和Conners父母量表测验结果均显著改善,同组治疗前后比较差异具有统计学意义(P0.05);且治疗后治疗组患儿上述观察指标比对照组的改善更明显,两组比较差异有统计学意义(P0.05)。结论托莫西汀治疗注意缺陷多动障碍临床效果显著,有利于患者认知功能的改善,具有一定的临床推广应用价值。

Comparison on clinical efficacy of atomoxetine and aripiprazole in treatment of children with attention deficit hyperactivity disorder

Objective To explore the clinical effect and safety of methimazole combined with ¹³¹I in treatment of hyperthyroidism.Methods Patients (83 cases) with hyperthyroidism accepted in Xi''an Jiaotong University Affiliated San Er Ling Yi Hospital from June 2012 to June 2015 were selected and divided into observation group with 42 cases and control group with 41 cases. Patients in observation group were given methimazole combined with ¹³¹I, and patients in control group were given PTU combined with ¹³¹I. Then the clinical effect, thyroid gland serological indexes, adverse reations, and reoccurrence rates of two groups were observed and compared.Results The total clinical efficacy of observation group was 95.24%, which was obviously higher than 70.73% of control group with statistically significance (P<0.05). TSH was getting higher after treatment of two groups, and T₃, T₄, FT₃, FT₄, TRAb, and TPOAb were getting lower after treatment of two groups. And TSH in the observation group was significantly higher than that in the control group, T₃, T₄, FT₃, and FT₄ were significantly lower than those in the control group (P<0.05). The adverse reaction rate of observation group (14.29%) was obviously lower than that of control group (46.34%) with statistically significance (P<0.05). The reoccurrence rate of observation group (4.76%) was obviously lower than that of control group (26.83%) with statistically significance (P<0.05).Conclusion Methimazole combined with ¹³¹I has good effect and safety in treatment of hyperthyroidism, which is worth of clinical application.