二甲双胍治疗糖耐量减低伴肥胖患者的临床观察

目的观察二甲双胍对于糖耐量减低伴肥胖患者的疗效。方法将72例患者随机分为对照组和治疗组各36例,对照组采用控制饮食与加强运动的生活方式干预治疗;治疗组在生活方式干预的基础上,口服二甲双胍治疗。将两组治疗后的葡萄糖耐量试验（OGTT）空腹及2h血糖、胰岛素、体重指数（BMI）、总胆固醇、甘油三酯、低密度脂蛋白以及胰岛素抵抗指数（HOMA-IR）的结果差异进行比较。结果治疗组治疗后BMI、BMI、FPG、2hPG、TG、TC、LDL-C、Fins各项指标较对照组改善明显,差异有统计学意义（P〈0.05）。结论二甲双胍可以用于糖耐量减低伴肥胖患者的治疗,能显著改善空腹及餐后血糖、血脂等各项指标。

Analysis of Efficacy of Metformin in Patients with Impaired Glucose Tolerance and Obesity

Objective To evaluate the effects of metformin in patients with impaired glucose tolerance and obesity. Methods 72 patients with impaired glucose tolerance and obesity were randomly divided into control group and treatment group. The control group（36 cases） was treated by diet control and exercise treatment, the treatment group（36 cases）took metformin.Compare the two groups after treatment on BMI,FPG,2 hPG, Fins,HOMA-IR. Results After treatment, BMI, BMI, FPG, 2 hPG, TG, TC, LDL-C, Fins indicators improved significantly in treatment group compared with the control group,and the difference was statistically significant （P0.05）.Conclusion Metformin can be used in the treamtment of patients with impaired glucose tolerance and obesity. Metformin can reduce BMI,FPG,2 hPG, Fins and HOMA-IR levels.