The lung to thorax transverse area ratio has a linear correlation with the observed to expected lung area to head circumference ratio in fetuses with congenital diaphragmatic hernias |
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Authors: | Noriaki Usui Hiroomi Okuyama Yutaka Kanamori Kouji Nagata Masahiro Hayakawa Noboru Inamura Shigehiro Takahashi Tomoaki Taguchi |
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Institution: | 1. Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka, Japan;2. Department of Pediatric Surgery, Hyogo College of Medicine, Hyogo, Japan;3. Division of Surgery, National Center for Child Health and Development, Tokyo, Japan;4. Department of Pediatric Surgery, Kyushu University, Fukuoka, Japan;5. Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan;6. Department of Pediatric Cardiology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan;g Division of Neonatology, National Center for Child Health and Development, Tokyo, Japan |
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Abstract: | Background/PurposeThe purpose of this study was to clarify the relationship between the lung to thorax transverse area ratio (L/T ratio) and the observed to expected lung area to head circumference ratio (O/E LHR), based on the results of a nationwide Japanese survey conducted in 2011, and to evaluate the compatibility of these prognostic predictors of fetal CDH.MethodsTwo hundred and forty-two prenatally diagnosed isolated CDH patients born between 2006 and 2010 were included in the present analysis. A regression analysis was conducted to investigate the relationship between the L/T ratio and the O/E LHR based on 191 simultaneous measurements of these parameters in 120 patients.ResultsThe linear regression equation between the L/T ratio and the O/E LHR was: L/T ratio = 0.0233 + (0.00222 × O/E LHR), (R = 0.847, p < 0.0001). According to this equation, 25% of the O/E LHR, the cut-off value used in the fetal intervention for CDH, was equivalent to an L/T ratio of 0.08, a commonly accepted cut-off value for identifying the most severe cases of fetal CDH.ConclusionsAs there is a positive correlation between the L/T ratio and the O/E LHR, these two parameters proved to be used interchangeably according to the linear regression equation. |
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Keywords: | Congenital diaphragmatic hernia Prenatal diagnosis Pulmonary hypoplasia Predictive parameter Prognostic factor |
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