Low Thymic Output,Peripheral Homeostasis Deregulation,and Hastened Regulatory T Cells Differentiation in Children with 22q11.2 Deletion Syndrome |
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| Authors: | Sara Ferrando-Martí nez,PhD,Raquel LorenteDolores Gurbindo,MD,PhD,M Isabel De José ,Manuel Leal,M Angeles Muñ oz-Ferná ndez,Rafael Correa-Rocha |
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| Affiliation: | 1 Laboratory of Molecular Immunobiology, Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain;2 Laboratorio de Inmunovirología, Instituto de Biomedicina de Sevilla (IBIS), Unidad clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain;3 Sección de Inmunopediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain;4 Servicio de Enfermedades Infecciosas Infantil, Hospital Universitario “La Paz”, Madrid, Spain;5 Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain |
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| Abstract: | |
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| Keywords: | β-TREC, DβJβ-T&minus cell receptor excision circle IL, Interleukin IL-7Rα, IL-7-receptor chain α PBMC, Peripheral blood mononuclear cell PCR, Polymerase chain reaction sj/β-TREC, Signal-joint/DβJβ-T cell receptor excision circle sj-TREC, Signal-joint T-cell receptor excision circles Treg, Regulatory T cells |
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