多囊卵巢综合征患者临床促排卵转体外受精-胚胎移植分析

目的:探讨应用克罗米芬(CC) 人尿促性腺激素(HMG) 人绒毛膜促性腺激素(HCG)促排卵与行超促排卵的多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVFF-ET)结局的差异。方法:常规门诊促排卵因卵泡发育过多转为IVF-ET患者12例(A组);应用促性腺激素释放激素激动剂(GnRH-a)常规长方案或短方案IVF-ET的PCOS患者17例(B组),对2组的促性腺激素(Gn)用量、促排卵天数、获卵数以及临床妊娠率等指标进行比较。结果:2组患者促排卵天数、受精率、胚胎移植数及临床妊娠率差异无统计学意义(P>0.05);A组患者Gn用量比B组患者用量少,但差异无统计学意义(P>0.05);A组患者平均获卵数明显少于B组(P<0.05);A组患者胚胎种植率高于B组,差异有统计学意义(P<0.05)。结论:PCOS患者应用CC HMG HCG进行促排卵,如卵泡发育过多,可改为IVF-ET,这是一种有效的挽救周期的治疗方法。

Analysis of PCOS Patients in Normal Ovarian Stimulation and IVF-ET

Objective: To investigate and compare the outcomes of PCOS patients in IVF-ET with and without GnRH-a. Methods: The days of Gn using,dosage of Gn,No. of egg retrieval and clinical pregnancy rate were compared between the 12 clincal stimulation patients using CC HMG HCG protocol without GnRH-a(group A) and 17 IVF-ET patients using GnRH-a(group B). Results: There was no difference of dosage of Gn,duration of Gn,E2 level of HCG day,insemination rate,implatation rate and pregnancy rate between group A and B. There was a significant difference in the No. of egg retrieval and between group A and group B(P < 0.05). Conclusion: If there is too much follicle growth in PCOS patients in clinical ovarian stimulation,converting to the IVF-ET without down regulation is another way to achieve the expected results in PCOS patients.