| 自身免疫病血瘀证患者自由基损伤的研究 |
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| 引用本文： | 葛金文,田应翠.自身免疫病血瘀证患者自由基损伤的研究[J].湖南中医药大学学报,1994,14(3):47-50. |
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| 作者姓名： | 葛金文 田应翠 |
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| 作者单位： | 本院附属第一医院 |
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| 摘 要： | 本文检测了３８例自身免疫病患者红细胞超氧化物歧化酶活性（Ｅｒｙ－ＳＯＤＡ），全血谷脱甘肽过氧化物醇（ＧＳＨ－Ｐｘ）活性及血浆丙二醛（ＭＤＡ）含量。结果表明；与正常对照组比较，自身免疫病组Ｅｒｙ－ＳＯＤＡ显著下降，ＧＳＨ－Ｐｘ活性和ＭＤＡ含量明显升高。血瘀证组与非血瘀证组比较，ＧＳＨ－Ｐｘ活性升高具有显著意义，（Ｐ＜０．０１），而Ｅｒｙ－ＳＯＤＡ降低和ＭＤＡ升高经统计学处理无显著意义（Ｐ＞０．０５）。提示自身免疫病的发生、发展与自由基损伤有密切关系，并且血瘀证患者自由基损伤程度更加严重。
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| 关 键 词： | 自身免疫性疾 血瘀 病理学 自由基 |
STUDY ON FREER ADICALS INJURY IN BLOOD STASISSYNDROME OF AUTOIMMUNE DISEASE |
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| Ge Jinwen,el al.STUDY ON FREER ADICALS INJURY IN BLOOD STASISSYNDROME OF AUTOIMMUNE DISEASE[J].Journal of Traditional Chinese Medicine University of Hunan,1994,14(3):47-50. |
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| Authors: | Ge Jinwen el al |
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| Institution: | Research Iaboratory For Thrombosis Haeinoetasis 410007 |
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| Abstract: | Author determined malondialdehyde(MDA) contents in plasma,orythrocyte superoxide dismutase activities(Ery-SODA) and blood glutathione peroxidase(GSH-Px) activities for 38 cases of autoimmune disease(AID).The results showed thatEry-SODA in AID group and Blood Stasis Syndrome(BSS)group significantly decrease andGSH-Px activities and MDA Conents markedly increase compared with healthy controlgroup They also showed that GSH-Px activities markedly increase and the decrease ofEry-SODA and the increase of MDA contents in BSS group have no statistical significancecompared with Non-Blood Stasis Syndrome group.All above suggested that free radicals in-ury may participate in the occurrence of AID and BSS of AID. |
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| Keywords: | Auttoimmune disease / pathology free radicals Superoxidedismutased / blood gutathione peroxidases / blood malondialehyde/blood bloodstasis / pathology |
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