| 分泌型卷曲相关蛋白在肿瘤中的研究进展 |
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| 引用本文： | 郑芸,陈龙邦. 分泌型卷曲相关蛋白在肿瘤中的研究进展[J]. 癌症进展, 2009, 7(3): 291-295,290 |
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| 作者姓名： | 郑芸 陈龙邦 |
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| 作者单位： | 第二军医大学南京临床医学院,南京军区南京总医院肿瘤内科,南京,210002;第二军医大学南京临床医学院,南京军区南京总医院肿瘤内科,南京,210002 |
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| 摘 要： | Wnt信号通路在许多生物学过程中发挥重要作用，异常的Wnt信号激活与肿瘤形成有关。分泌型卷曲相关蛋白（SFRPs）是Wnt信号的拮抗因子，在肿瘤中常由于启动子高甲基化而表达沉默，因此被认为是一种抑癌基因。但SFPRs在某些情况下也促进细胞增殖。本文综述近年来SFRPs在肿瘤中的研究进展。
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| 关 键 词： | SFRPs 甲基化 Wnt信号通路 肿瘤 |
Role of secreted frizzled- related proteins in cancer |
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| Zheng Yun,Chen Longbang. Role of secreted frizzled- related proteins in cancer[J]. Oncology Progress, 2009, 7(3): 291-295,290 |
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| Authors: | Zheng Yun Chen Longbang |
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| Affiliation: | Zheng Yun ChenLongbang(Nanjing Clinical School of the Second Military Medical University, Department of Ontology, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China) |
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| Abstract: | The Wnt signaling pathway is implicated in a variety of biological processes. Aberrant Wnt activation has been linked to tumor formation. Secreted frizzled - related proteins （SFRPs） are Wnt antagonists, and accumulating evidence has suggested that SFRPs act as tumor suppressors because their expression is frequently silenced in cancer by promoter hypermethylation. However, SFRPs may also promote cell growth in some contexts. This paper reviews the advances of SFRPs in cancer research recently. |
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| Keywords: | SFRPs |
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