| 洛伐他汀脂质体的制备及表征 |
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| 引用本文： | 福西娅,贾俊婷,刘建平. 洛伐他汀脂质体的制备及表征[J]. 药学进展, 2011, 35(12): 566-570 |
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| 作者姓名： | 福西娅 贾俊婷 刘建平 |
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| 作者单位： | 中国药科大学药物制剂研究所,江苏南京,210009 |
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| 基金项目： | 国家"重大新药创制"科技重大专项 |
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| 摘 要： | 目的：研制洛伐他汀脂质体,考察其制备的影响因素,优化处方工艺,并对其特性进行表征。方法：采用薄膜分散法制备洛伐他汀脂质体,以包封率、粒径和Zeta电位为指标参数,考察表面活性剂、水合介质及药脂比对其制备的影响;并评价其理化性质及稳定性。结果：以脱氧胆酸钠-泊洛沙姆188（1∶2）为表面活性剂、去离子水为水合介质和药脂比为1∶40制备的洛伐他汀脂质体具有最佳的包封率（〉90%）、粒径（90～110 nm,分布系数为0.32）和Zeta电位（-35～-39 mV）;其外观圆整,内部具指纹状结构;在4℃下放置30 d,包封率、粒径及Zeta电位均无明显变化。结论：采用薄膜分散法制备的洛伐他汀脂质体具有良好的理化特性及稳定性。
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| 关 键 词： | 洛伐他汀 脂质体 包封率 粒径 Zeta电位 稳定性 |
Preparation and Characterization of Lovastatin-loaded Liposomes |
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| FU Xi-ya,JIA Jun-ting,LIU Jian-ping. Preparation and Characterization of Lovastatin-loaded Liposomes[J]. Progress in Pharmaceutical Sciences, 2011, 35(12): 566-570 |
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| Authors: | FU Xi-ya JIA Jun-ting LIU Jian-ping |
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| Affiliation: | FU Xi-ya,JIA Jun-ting,LIU Jian-ping(Institute of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Objective:To prepare lovastatin loaded liposomes(LTLs),to study the influencing factors,to optimize their formulation and to characterize their properties.Methods:LTLs were prepared by film dispersion method.The influences of surfactants,hydrating media and drug-lipid ratios on their preparation were investigated using entrapment efficiency(EE),particle-size,and Zeta potential as indicators.Their physicochemical properties and stability were evaluated.Results:LTLs prepared using the optimal formulation,DOC-... |
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| Keywords: | lovastatin liposome entrapment efficiency particle-size Zeta potential stability |
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