| 透明质酸及其衍生物用作药物载体的研究进展 |
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| 引用本文： | 俞晨洁,张莉,李红玫,李园珂,赵震,吴非,姚静,周建平.透明质酸及其衍生物用作药物载体的研究进展[J].药学进展,2011,35(12):543-549. |
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| 作者姓名： | 俞晨洁 张莉 李红玫 李园珂 赵震 吴非 姚静 周建平 |
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| 作者单位： | 中国药科大学药剂学教研室,江苏南京,210009 |
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| 基金项目： | 国家"重大新药创制"科技重大专项，国家自然科学基金，江苏省"六大人才高峰"项目 |
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| 摘 要： | 鉴于透明质酸具有良好的生物相容性、生物可降解性、无免疫原性,以及对肿瘤细胞的高亲和性,透明质酸及其衍生物作为新型药物载体的研究备受瞩目。综述近年来透明质酸及其衍生物作为药物载体的应用研究进展,主要包括纳米粒、凝胶、阳离子聚合物基因载体等方面。
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| 关 键 词： | 透明质酸 衍生物 药物载体 |
Research Advances on Hyaluronic Acid and Its Derivatives as Drug Carriers |
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| YU Chen-jie,ZHANG Li,LI Hong-mei,LI Yuan-ke,ZHAO Zhen,WU Fei,YAO Jing,ZHOU Jian-ping.Research Advances on Hyaluronic Acid and Its Derivatives as Drug Carriers[J].Progress in Pharmaceutical Sciences,2011,35(12):543-549. |
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| Authors: | YU Chen-jie ZHANG Li LI Hong-mei LI Yuan-ke ZHAO Zhen WU Fei YAO Jing ZHOU Jian-ping |
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| Institution: | YU Chen-jie,ZHANG Li,LI Hong-mei,LI Yuan-ke,ZHAO Zhen,WU Fei,YAO Jing,ZHOU Jian-ping (Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Hyaluronic acid(HA) is a natural polysaccharide with the excellent properties such as biocompatible,biodegradable,and non-immunogenic characteristics.Besides,it demonstrates a high affinity state with tumor cells.Accordingly,HA and its derivatives as drug carriers have been paid a great attention by more and more researchers.In this paper,advances in research on the applications of HA and its derivatives as drug carriers were reviewed,including nanoparticle,hydrogel,cationic polymer gene carrier and so on. |
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| Keywords: | hyaluronic acid derivatives drug carrier |
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