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| 迷迭香酸对大鼠局灶性脑缺血再灌注损伤的保护作用及机理探讨 | |
| 引用本文： | 高丽萍,张文斌,景玉宏,郑荣梁.迷迭香酸对大鼠局灶性脑缺血再灌注损伤的保护作用及机理探讨[J].亚太传统医药,2011,7(12):8-10. |
| 作者姓名： | 高丽萍 张文斌 景玉宏 郑荣梁 |
| 作者单位： | 1. 兰州大学基础医学院,甘肃兰州,730000 2. 上海交通大学药学院,上海,200240 3. 兰州大学生命科学学院,甘肃兰州,730000 |
| 基金项目： | 甘肃省自然科学基金资助项目，甘肃省新药临床前研究重点实验室开放基金课题 |
| 摘 要： | 目的:探讨迷迭香酸对大鼠局灶性脑缺血再灌注损伤的保护作用及机理。方法:采用线栓法制作局灶性脑缺血再灌注模型,观察大鼠行为学改变。测定脑梗塞体积、血清MDA含量、SOD和GSH-Px的活性。结果:迷迭香酸能够显著改善脑缺血再灌注大鼠的行为障碍和减少脑梗塞体积,可以显著抑制脑缺血再灌注大鼠MDA的生成,明显升高SOD和GSH-Px的活性。结论:迷迭香酸对脑缺血再灌注损伤具有明显的保护作用,抗氧化作用是其发挥脑缺血保护作用的机制之一。 |
| 关 键 词： | 迷迭香酸 局灶性脑缺血再灌注损伤 SOD MDA GSH-Px |
The Protection and Mechanism of Rosmarinic Acid on Focal Cerebral Ischemia-Reperfusion in Rats |
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| Gao Liping,Zhang Wenbin,Jing Yuhong,Zheng Rongliang.The Protection and Mechanism of Rosmarinic Acid on Focal Cerebral Ischemia-Reperfusion in Rats[J].Asia-Pacific Traditional Medicine,2011,7(12):8-10. | |
| Authors: | Gao Liping Zhang Wenbin Jing Yuhong Zheng Rongliang |
| Institution: | 1.Lanzhou University,Lanzhou 730000,China; 2.Shanghai Jiao Tong University School of Pharmacy,Shanghai 200240,China) |
| Abstract: | Objective： To investigate the protection and mechanism of rosmarinic acid on focal cerebral in rats.Methods： Focal cerebral ischemia-reperfusion model was made with suture-occluded method in rats.The behavior obstacles of rats were observed.The volume of cerebral infarction,the level of MDA in serum,the activities of SOD and GSH-Px in serum were measured.Results： Rosmarinic acid could effectively ameliorate behavior obstacles and decrease the volume of cerebral infarction in ischemia-reperfusion injuryed rats.Moreover,it could decrease MDA level and increase the activities of SOD and GSH-Px in serum.Conclusion：Rosmarinic acid has significant protection again cerebral ischemia-reperfusion injury.This effect may be related to its antioxidant property. |
| Keywords: | Rosmarinic Acid Cerebral Ischemia-Reperfusion Injury SOD MDA GSH-Px |
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