Stimulation of human platelet adenylate cyclase by prostaglandin D2 |
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| Authors: | D C Mills D E Macfarlane |
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| Affiliation: | Thrombosis Research Center Temple University Health Sciences Center 3400 North Broad Street Philadelphia, Pennsylvania 19140 USA |
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| Abstract: | Prostaglandin D2 (PGD2) stimulates the formation of cyclic AMP in human platelets measured as the incorporation of radio-activity from previously labelled intracellular nucleotides. In this action it is similar to, and more powerful than PGE1. Both inhibition of platelet aggregation and stimulation of cyclic AMP accumulation by PGD2 and by PGE1 are potentiated by an inhibitor of platelet phosphodiesterase. A number of minor differences in the response of platelets to PGD2 and PGE1 suggest the existence of at least two prostaglandin receptors influencing a single adenylate cyclase. |
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