大肠癌患者手术前后外周血生长抑素的变化及其与机体免疫功能的关系

目的：研究大肠癌患者手术前后生长抑素（ＳＳ）的变化及其与机体免疫功能的关系。方法：观察２５例大肠癌患者手术前后外周血ＳＳ水平及免疫功能的改变，并分析两者变化的相关性。结果：大肠癌组术前外周血ＳＳ水平明显高于对照组（ｐ〈０．０１）；术后较术前明显下降（ｐ〈０．０１），且与对照组相比无显著差异。而大肠癌组术前ＮＫ细胞活性、ＣＤ４＾＋Ｔ细胞比例、淋巴细胞增值能力以及ＩＬ－２诱生水平均显著低于对照组（ｐ〉

Correlation between plasma somatostatin and immune function pre- or post-operatively in patients with colorectal cancer

Objective: To investigate the changes in plasma somatostatin and its correlation with immune function in patients with colorectal cancer. Methods: Twenty five cases of colorectal cancer were collected to detect the plasma somatostatin and the immune function pre or post operatively, and the correlation between the plasma somatostatin and the immune function was analyzed. Results: The plasma somatostatin levels in patients with colorectal cancer were significantly higher than that in the controls. After operation, the PSS levels reduced markedly and showed no significant changes compared with the control groups. The NK activity, the proportion of CD4 + T subtype, the proliferation of lymphocytes and the induced IL 2 levels were markedly improved compared with that before operation in patient, but it was still significantly different compared with the control group. The proportion of CD8 + T subtype pre and post operation remained unchanged. Both post and pre operative PSS levels had a significant negative correlation with NK activity, the proportion of CD4 + T subtype, the proliferation of lymphocytes and IL 2 level. Conclusion: High level of PSS is related to the colorectal tumor existence, and there is a strong negative correlation between PSS and immune function in patients with colorectal cancer.