肝癌最佳肿瘤标记物及相关指标群的研究

目的：探讨肝癌的最佳标记组合。方法：收集肝癌病人45例和62例健康成人，检测AFP、ERBB-2、IL-2R等27种指标，计算各指标的特异性、阳性预期值、敏感性、阴性预期值、总有效率，及上述5项的平均值。结果：平均值排序前6位的是：TPA、GGT、AFP、FU、AKP、PU；选取AFP=FU、TPA三标记物的敏感性达97.06%，其中前二基的敏感性为92.70%，三项中任一项阳性所致的特异性为63.68%。结论：AFP、FU、TPA是检测肝癌的最佳指标组合。多指标联合检测较单指标检测有更高的特异性的敏感性。

Selection of Optimal Indices Combination for Diagnosis of Liver Cancer

Objective:To explore and evaluate the optimal indices combination for the diagnosis of liver cancer Methods:Twenty seven indices were detected in 45 patients with liver cancer and 62 health adults.The specificity,positive predictability,sensitivity,negative predictability,total availability and average value of all the above values were calculated.Results:Average values of TPA,GGT,AFP,AKP,PU were higher than others.The sensitivity of combining detection of AFP,FU,and TPA was as high as 97.06%, while that of AFP and FU 92.70%.The specificity of any of AFP,FU and TPA was 63.68%.Conclusion:Combining detection of AFP,FU and TPA is the optimal selection for liver cancer screening.Combining detection of indices produces higher sensitivity and specificity than solo detection.