Ezrin和c-Met在胃癌组织中的表达及意义

目的研究Ezrin和c-Met在胃癌组织中的表达及其临床意义。方法应用免疫组织化学法检测45例胃癌、25例胃腺瘤、20例正常胃黏膜组织中Ezrin和c-Met的表达水平,分析Ezrin和c-Met的表达与各临床病理因素的关系。结果胃癌组织中Ezrin和c-Met的表达水平明显高于胃腺瘤组织及正常胃黏膜组织(P<0.05)。Ezrin和c-Met的表达水平与肿瘤的浸润深度、分化程度及有无淋巴结转移/远处转移有关(P<0.05),与性别、年龄及肿瘤大小无关(P>0.05),两者在胃癌组织中的表达呈正相关关系(r=0.603,P<0.001)。结论 Ezrin和c-Met与胃癌的发生、侵袭、转移密切相关,二者在胃癌发生、发展过程中可能具有协同作用,联合检测Ezrin和c-Met的表达水平可能为胃癌预后判断提供依据。

Expression and significance of Ezrin and c-Met in gastric carcinoma

Objective To investigate the expression of Ezrin and c-Met in gastric carcinoma and its clinical significance. Methods Immunohistochemistry was applied to detect the expression of Ezrin and c-Met in 45 cases of gastric carcinoma,25 cases of gastric adenoma and 20 cases of normal gastric mucosa.The relationships between their expression and the clinicopathological parameters were analyzed. Results The expression of Ezrin and c-Met in gastric carcinoma was significantly higher than those in gastric adenoma and normal gastric mucosa(P<0.05).The expression of Ezrin and c-Met was related to the invasion depth,the degree of differentiation and lymph node metastasis or distant metastasis(P<0.05),but not to gender,age and tumor diameter(P>0.05).A positive correlation was found between Ezrin and c-Met expression in gastric carcinoma tissues(r=0.603,P<0.001). Conclusion Ezrin and c-Met are closely related to the development,invasion and metastasis of gastric carcinoma.Ezrin and c-Met are synergic in the occurrence and development of gastric carcinoma.Combined detection of Ezrin and c-Met is helpful for clinical doctors to predict the prognosis in patients with gastric carcinoma.