门冬胰岛素30和赖脯胰岛素50对2型糖尿病疗效的对比观察

目的比较门冬胰岛素30与赖脯胰岛素50对2型糖尿病患者的疗效。方法住院2型糖尿病患者60例,入院后均空腹抽取静脉血查糖化血红蛋白,并监测空腹、午餐及晚餐后2 h血糖和凌晨3:00血糖。监测2 d后签署知情同意书并随机分为两组,分别应用门冬胰岛素30和赖脯胰岛素50治疗2周。出院后电话随访3个月观察血糖下降情况及低血糖发生率,评价两种药物对糖化血红蛋白的影响及降糖治疗支出的情况。结果经过3个月治疗,两组空腹血糖及糖化血红蛋白均较入院时显著下降,但组间差异无统计学意义(P>0.05);赖脯胰岛素50组餐后2 h血糖下降较门冬胰岛素30组显著(P<0.05);赖脯胰岛素50组低血糖发生率及降糖费用明显低于门冬胰岛素30组(P<0.05)。结论门冬胰岛素30与赖脯胰岛素50对空腹血糖及糖化血红蛋白的影响无明显差异,但赖脯胰岛素50对餐后血糖控制明显优于门冬胰岛素30,且低血糖发生率及花费更少。

Comparative study on NovoRapid Mix30 and Humalog Mix50 in the treatment of type 2 diabetic patients

Objective To compare the clinical efficacy of NovoMix30 and Humalog Mix50 in the treatment of type 2 diabetes mellitus(DM). Methods A randomized,controlled clinical trial of NovoMix30 and Humalog Mix50 was performed in the type 2 diabetic patients.Sixty patients were divided into two groups.The patients were treated with NovoMix30 in group A,and Humalog Mix50 in group B.The levels of fasting plasma glucose(FPG),postprandial plasma glucose(PPG),hypoglycaemia,glucosylated hemoglobulin A1c(HbA1c) were compared before and after the treatment for 2 weeks,3 months. Results After treatment for 2 weeks,the levels of HbA1c,FPG and PPG in two groups were all decreased significantly compared with the baselines.The decreased level of PPG 2 h in group B was significantly higher than in group A(P<0.05).Incidence of hypoglycaemia in group A was higher than in group B(P<0.05).The medical costs of decreasing glucose in group A was higher than in group B. Conclusion Humalog Mix50 is better than NovoMix30 for controling levels of PPG 2 h in patients with type 2 diabetes mellitus,and Humalog Mix50 is more economy.