反复呼吸道感染患儿IgG亚类与血锌相关性的临床研究

目的：探讨反复呼吸道感染（RRTI）患儿血清IgG亚类与血锌之间的关系，为临床治疗小儿反复呼吸道感染提供一定的理论依据。方法：采用免疫散射比浊法测定IgG、IgG亚类含量，利用原子吸收法测定血锌含量。结果：64例RRTI患儿IgG2、IgG4及血锌水平明显低于对照组；IgG亚类缺陷28例，检出率为43．75％（28／64），在检出的患儿中IgG。缺陷发生率最高，为35．71％（10／28），联合缺陷以IgG2＋IgG4最多，发生率为21．42％（6／28）。结论：RRTI患儿虽然IgG正常但存在IgG亚类异常；RRTI患儿血锌水平低于正常儿童，IgG2、IgG4异常与低血锌有关。

A Clinical Study of Correlations between IgG Subclasses and Blood Zinc in Children with Recurrent Respiratory Tract Infection

Objective： To explore the relationship between IgG subclasses and blood zinc in children with recurrent respiratory tract infection （RRTI）, which may provide certain theory basis on the clinical treatment of RRTI. Methods： The levels of serum IgG and IgG subclasses were detected by immune nephelometry. The levels of blood zinc were detected by atomic absorption method. Results： Among the sixty-four cases of children with RRTI, there were twenty-eight cases with IgG subclass deficiency; the positive rate was 43.75% （28/64）. IgG4 deficient was the highest in single deficiency, which accounted for 35.71% （10/28）; IgG~ ＋IgG4 was the highest in joint defects, which accounted for 21.42% （6/28）. Conclusions： Although the serum levels of IgG in children with RRTI were normal, they did exist abnormal in IgG subclasses. The levels of blood zinc in the patients were lower than those in the normal children. There were some relationships between the decreased levels of IgG2, IgG4 and blood zinc deficiency.