Evaluation of Patient-Reported Outcome in Subjects Treated Medically for Acute Pancreatitis: A Follow-Up Study |
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| Authors: | R Pezzilli AM Morselli-Labate D Campana R Casadei E Brocchi R Corinaldesi |
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| Institution: | 1. Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark;2. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark;3. Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark;4. Centre for Nutrition and Bowel Disease, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark;1. Digestive Service, Complejo Hospitalario de Navarra, Pamplona, Spain;2. Digestive Service, Hospital Universitario Araba, Álava, Spain;3. Digestive Service, H. La Paz, Madrid, Spain;4. Digestive Service, H. Universitario Miguel Servet, Zaragoza, Spain;5. Digestive Service, H. Universitario de Cruces, Vizcaya, Spain;6. Digestive Service, H. Universitario Reina Sofia, Córdoba, Spain;7. Digestive Service, Complejo Hospitalario Universitario de Orense, Orense, Spain;8. Digestive Service, H. 12 de Octubre, Madrid, Spain;9. Digestive Service, H. San Eloy, Vizcaya, Spain;10. Medical Department Mylan, Spain;11. Department of Gastroenterology, H. General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL – Fundación FISABIO), Alicante, Spain;1. Department of HPB Surgery, University Hospitals of Leicester, UK;2. Dietetics Department, University Hospitals of Leicester, UK;3. Department of Anaesthesia, University Hospitals of Leicester, UK;4. Department of Medical Psychology, Leicester Partnership Trust, UK;1. Department of Surgery, Medical University of South Carolina, Charleston, SC;2. Department of Psychology and Behavioral Sciences, Medical University of South Carolina, Charleston, SC;1. Department of Biology, University of Toronto at Mississauga, 3359 Mississauga Rd. N., Mississauga, Ontario L5L 1C6, Canada;2. Department of Cell and Systems Biology, University of Toronto, 25 Harbord St., Toronto, Ontario M5S 3G5, Canada |
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| Abstract: | Aims: To explore the quality of life in patients treated medically during the acute phase of pancreatitis as well as at 2 and 12 months after discharge from the hospital. Patients: 40 patients were studied. The etiology of the pancreatitis was biliary causes in 31 patients and non-biliary causes in 9; mild disease was present in 29 patients and severe disease in 11. 30 patients completed the two surveys at 2 and 12 months after hospital discharge. Methods: The SF-12 and EORTC QLQ-C30 questionnaires were used for the purpose of the study. Results: The two physical and mental component summaries of SF-12, all the domains of EORTC QLQ-C30 (except for physical functioning and cognitive functioning) and some symptom scales of EORTC QLQ-C30 (fatigue, nausea/ vomiting, pain, and constipation) were significantly impaired during the acute phase of pancreatitis. There was a significant improvement in the SF-12 physical component summary, and global health, role functioning, social functioning, nausea/vomiting, pain, dyspnea, and financial difficulties (EORTC QLQ-C30) at 2 months after discharge as compared to the basal evaluation. Similar results were found after 12 months except for the mental component score at 12-month evaluation, which was significantly impaired in acute pancreatitis patients in comparison to the norms. The physical functioning of the EORTC QLQ-C30 at basal evaluation was significantly impaired in patients with severe pancreatitis in comparison to patients with mild pancreatitis. Conclusions: Two different patterns can be recognized in the quality of life of patients with acute pancreatitis: physical impairment is immediately present followed by mental impairment which appears progressively in the follow-up period. |
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