Effects of ovulation induction agents on ovarian surface epithelium in rats |
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| Authors: | Zeynep Ozcan Husnu Celik Bilgin Gurates Hanifi Ibrahim Ozercan Fethi Hanay Mehmet Nalbant Zeynep Dogan |
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| Institution: | 1. Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia;2. Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia;1. Department of Obstetrics and Gynecology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Institut Universitaire de Cancérologie, Paris, France;2. Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_S 707, “Epidemiology, Information Systems, Modeling”, Université Pierre et Marie Curie, Paris, France;3. INSERM UMR_S 938, Université Pierre et Marie Curie, Paris, France;4. Department of Gynecologic Surgery and INSERM U 10-30, Institut Gustave Roussy, Villejuif, and Université Paris-Sud, Le Kremlin Bicêtre, France;5. Department of Obstetrics and Gynecology, Centre hospitalier Universitaire and INSERM ERI-12, Université de Picardie Jules Vernes, Amiens, France;1. Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia;2. Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia;1. Division of Gynecology, European Institute of Oncology, Milan, Italy;2. Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy;3. Division of Gynecology, University of Sacred Heart, Rome, Italy;4. Division of Gynecology and Obstetrics, Università Campus Bio-Medico of Rome, Rome, Italy;1. Cancer Center, The First Hospital of Jilin University, Changchun 130021, China;2. The Institute of Theoretical Chemistry, State Key Laboratory of Theoretical and Computational Chemistry, Jilin University, Changchun 130023, China;3. Department of Spinal Surgery, The First Hospital of Jilin University, Changchun 130021, China;4. Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, China;5. Departments of Pediatrics, Radiation Oncology, Pharmacology, and Toxicology, University of Louisville, Louisville, KY 40292, USA;1. Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka-shi, Saitama 349-0294, Japan;2. Courses of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan |
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| Abstract: | The aim of this study was to examine the effects of ovulation induction agents on the ovarian surface epithelium in rats. Sixty adult females were randomly divided into six groups, each containing 10 rats. In four of these groups ovulation induction was applied with six cycles of clomiphene citrate, human menopausal gonadotrophin (HMG), recombinant FSH (rFSH) or human chorionic gonadotrophin (HCG), respectively, followed by unilateral oophorectomy, and another six cycles of the same treatment. After a total of 12 cycles of ovulation induction, the remaining ovary was taken out and the alterations in ovarian surface epithelium were examined. No malignancies were observed on the ovarian surface epithelium of the rats that were given clomiphene citrate, rFSH or HMG as ovulation induction agents, while identification rates of histopathological parameters constituting epithelial dysplasia were found to be significant (P < 0.05). There was no significant dysplasia in the epithelium of the group which was given HCG only, relative to control groups. The findings suggest that the ovulation induction agents except for HCG bring about dysplasia in the ovarian surface epithelium. It is not clear whether these dysplasias are precursory lesions of ovarian malignancies. |
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