| 中医药抑制肿瘤侵袭转移的IL-8-EMT调控机制研究进展 |
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| 引用本文： | 张云龙,施俊. 中医药抑制肿瘤侵袭转移的IL-8-EMT调控机制研究进展[J]. 中国中医药现代远程教育, 2020, 0(1): 134-137 |
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| 作者姓名： | 张云龙 施俊 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院肿瘤科 |
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| 基金项目： | 国家自然科学基金【No.81573762】;上海中医药大学附属岳阳医院第十一批大学生科创项目【No.JX61.08.100】 |
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| 摘 要： | 上皮间质转化(EMT)是肿瘤细胞侵袭与转移的关键步骤,现代研究发现白介素-8(IL-8)与EMT密切相关,其通过ERK、AKT、AKT1信号通路和IL-8/CXCR1信号轴参与EMT的进程。研究表明中医药能有效抑制肿瘤侵袭转移,近年来研究发现IL-8、EMT调控是中医药抑制肿瘤侵袭与转移的关键机制,中药干预不仅可以通过下调IL-8表达,而且还可以抑制甚至逆转EMT来抑制肿瘤的侵袭转移,更有研究证实中医药可以调控IL-8诱导下肿瘤EMT进程。
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| 关 键 词： | 中医药疗法 白介素-8 上皮间质转化 癌证 侵袭 肿瘤转移 |
Research Progress on Inhibition of Tumor Invasion and Metastasis by Traditional Chinese Medicine through IL-8-EMT Regulation |
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| ZHANG Yunlong,SHI Jun. Research Progress on Inhibition of Tumor Invasion and Metastasis by Traditional Chinese Medicine through IL-8-EMT Regulation[J]. Chinese Medicine Modern Distance Education of China, 2020, 0(1): 134-137 |
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| Authors: | ZHANG Yunlong SHI Jun |
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| Affiliation: | (Oncology Department,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China) |
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| Abstract: | Epithelial-mesenchymal transition(EMT) is a key step in tumor cell invasion and metastasis. Recent studies indicated that interleukin-8(IL-8) is closely related to EMT, which affects the progression of EMT through the ERK, AKT, AKT1 signaling pathways and IL-8/CXCR1 axis. In recent years, clinical and experimental studies have confirmed that traditional Chinese medicine can effectively inhibit tumor invasion and metastasis. The latest researches found that IL-8 and EMT may be a key mechanism for TCM to inhibit tumor invasion and metastasis. TCM can inhibit the invasion and metastasis of tumor not only by down-regulating IL-8, but also inhibiting or even reversing EMT to inhibit tumor invasion and metastasis. More studies have confirmed that TCM regulates IL-8-induced EMT of tumor. |
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| Keywords: | traditional Chinese medicine interleukin-8 epithelial-mesenchymal transition cancer invasion metastasis |
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