Update on the Molecular Pathogenesis of Pancreatic Tumors Other than Common Ductal Adenocarcinoma |
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| Authors: | D Antonello S Gobbo V Corbo B Sipos NR Lemoine A Scarpa |
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| Institution: | 1. Dipartimento di Patologia, Universitá di Verona, Verona, Italy;2. Department of Pathology, University of Kiel, Kiel, Germany;3. Institute of Cancer and CR-UK Clinical Centre, Barts and The London School of Medicine, London, UK;1. Klinik für Radiologie, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Germany;2. Medizinische Klinik m.S. Hepatologie Gastroenterologie, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Germany;3. Institut für Pathologie, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Germany;4. Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Germany;1. Department of General Pathology, Second University of Naples, Napoli, Italy;2. Clinica Pineta Grande, Castelvolturno, Italy;3. Thermogenesis Corporation, Rancho Cordova, California, USA;1. Department of Biomedical Sciences and Morpho-functional Imaging, Polyclinic University of Messina, Messina, Italy;2. Department of Neurosciences, Polyclinic University of Messina, Messina, Italy;1. Department of General Surgery, The Ohio State University College of Medicine, Columbus, Ohio;2. Division of Surgical Oncology, Department of General Surgery, The Ohio State University College of Medicine, Columbus, Ohio;3. Center for Biostatistics, The Ohio State University, Columbus, Ohio;4. Division of Hematology and Oncology, and Bone Marrow Transplantation, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children''s Hospital, Columbus, Ohio;5. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, College of Medicine, The Ohio State University College of Medicine, Columbus, Ohio;6. Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children''s Hospital, Columbus, Ohio;1. Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy;2. San Raffaele Scientific Institute Milano, Torino, Italy;3. Laboratory of Microbiology and Molecular Biology, Ospedale Amedeo di Savoia, ASLTO2, Torino, Italy |
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| Abstract: | Purpose: Although ductal adenocarcinoma is the most common and well known pancreatic tumor type, other distinct epithelial neoplasms affecting the pancreas that show different symptoms, biological behaviors and outcomes are becoming more frequently recognized and documented. Pancreatic epithelial tumors may be separated into ductal and nonductal neoplasms. The former group includes pancreatic ductal adenocarcinoma, intraductal papillary-mucinous tumor, mucinous cystic tumor and serous cystic tumor. The latter group includes pancreatic endocrine tumor, pancreatic acinar cell carcinoma, pancreatoblastoma and solid-pseudopapillary tumor. The aim of this review is to summarize recently acquired knowledge regarding the molecular characterization of these uncommon pancreatic epithelial neoplasms. Recent Findings: Molecular studies of uncommon pancreatic epithelial tumors suggest that the different morphological entities are associated with distinct molecular profiles, highlighting the involvement of different molecular pathways leading to the development of each subtype of pancreatic neoplasm. Conclusion: The correct classification of rare pancreatic epithelial tumors and the identification of their characteristic molecular aspects is the fundamental starting point in identifying novel diagnostic molecular tools and new targets for innovative therapeutic Strategies. |
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