| 美洛昔康的致突变研究 |
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| 引用本文： | 李练兵,马明福,李新生,蔡敏.美洛昔康的致突变研究[J].癌变．畸变．突变,2002,14(2):115-117. |
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| 作者姓名： | 李练兵 马明福 李新生 蔡敏 |
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| 作者单位： | 重庆市计划生育科学研究所基础研究室,重庆 400020 |
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| 摘 要： | 目的:研究美洛昔康是否有潜在的遗传危害。方法:利用Ames 试验、染色体畸变试验和微核试验对美洛昔康的突变性进行研究。结果:在±S9mix 条件下,各剂量组对TA97 、TA98 、TA100 和TA102 菌株无诱发回复突变菌落数增加作用;对中国仓鼠成纤维细胞(CHL) 染色体无畸变作用;以240 mg/ kg·bw、120 mg/ kg·bw、48 mg/ kg·bw 和16 mg/ kg·bw 的美洛昔康对小鼠骨髓嗜多染红细胞的微核细胞率无增加作用。结论:在本实验条件下,美洛昔康对Ames 试验、染色体畸变试验和微核试验无致突变效应。
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| 关 键 词： | 美洛昔康 Ames 试验 染色体畸变 微核 突变 |
| 文章编号： | 1004-616X(2002)02-0115-03 |
| 收稿时间： | 2001-06-30 |
| 修稿时间： | 2001年6月30日 |
STUDY ON THE MUTAGENICITY OF MELOXICAM |
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| LI Lian-bing,MA Ming-fu,LI Xin-Sheng,CAI Min.STUDY ON THE MUTAGENICITY OF MELOXICAM[J].Carcinogenesis,Teratogenesis and Mutagenesis,2002,14(2):115-117. |
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| Authors: | LI Lian-bing MA Ming-fu LI Xin-Sheng CAI Min |
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| Institution: | Chongqing Family Planning Scientific Research Institute,Chongqing 400020, China |
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| Abstract: | Purpose and Methods : To study the potential mutagenicity of meloxicam , Ames test was carried out in TA97 , TA98 , TA100 , TA102 strains , chromosomal aberration test in Chinese hamster lung fibroblast sand micronucleus test in polychromatic erythrocytes in mice with and without S9mix. Results : No increase in the number of revertant colonies was found in the Ames test at a dose range from 0. 2 to 5 000μg per plate. These results were also negative in the micronucleus test and in the chromosomal aberration test at doses from 16 to 240 mg/ kg·bw. Conclusion : The mutagenicity of meloxicam was not observed in this study. |
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| Keywords: | meloxicom Ames test chromosome aberration micronucleus |
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